Reaction Details |
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Target | Smoothened homolog |
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Ligand | BDBM50249522 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1622141 (CHEMBL3864493) |
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IC50 | 39±n/a nM |
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Citation | Liu, G; Xue, D; Yang, J; Wang, J; Liu, X; Huang, W; Li, J; Long, YQ; Tan, W; Zhang, A Design, Synthesis, and Pharmacological Evaluation of 2-(2,5-Dimethyl-5,6,7,8-tetrahydroquinolin-8-yl)-N-aryl Propanamides as Novel Smoothened (Smo) Antagonists. J Med Chem59:11050-11068 (2016) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Smoothened homolog |
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Name: | Smoothened homolog |
Synonyms: | SMO_MOUSE | Smo | Smoh |
Type: | PROTEIN |
Mol. Mass.: | 87472.73 |
Organism: | Mus musculus |
Description: | ChEMBL_1510377 |
Residue: | 793 |
Sequence: | MAAGRPVRGPELAPRRLLQLLLLVLLGGPGRGAALSGNVTGPGPHSASGSSRRDVPVTSP
PPPLLSHCGRAAHCEPLRYNVCLGSALPYGATTTLLAGDSDSQEEAHGKLVLWSGLRNAP
RCWAVIQPLLCAVYMPKCENDRVELPSRTLCQATRGPCAIVERERGWPDFLRCTPDHFPE
GCPNEVQNIKFNSSGQCEAPLVRTDNPKSWYEDVEGCGIQCQNPLFTEAEHQDMHSYIAA
FGAVTGLCTLFTLATFVADWRNSNRYPAVILFYVNACFFVGSIGWLAQFMDGARREIVCR
ADGTMRFGEPTSSETLSCVIIFVIVYYALMAGVVWFVVLTYAWHTSFKALGTTYQPLSGK
TSYFHLLTWSLPFVLTVAILAVAQVDGDSVSGICFVGYKNYRYRAGFVLAPIGLVLIVGG
YFLIRGVMTLFSIKSNHPGLLSEKAASKINETMLRLGIFGFLAFGFVLITFSCHFYDFFN
QAEWERSFRDYVLCQANVTIGLPTKKPIPDCEIKNRPSLLVEKINLFAMFGTGIAMSTWV
WTKATLLIWRRTWCRLTGHSDDEPKRIKKSKMIAKAFSKRRELLQNPGQELSFSMHTVSH
DGPVAGLAFDLNEPSADVSSAWAQHVTKMVARRGAILPQDVSVTPVATPVPPEEQANMWL
VEAEISPELEKRLGRKKKRRKRKKEVCPLRPAPELHHSAPVPATSAVPRLPQLPRQKCLV
AANAWGTGESCRQGAWTLVSNPFCPEPSPHQDPFLPGASAPRVWAQGRLQGLGSIHSRTN
LMEAEILDADSDF
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BDBM50249522 |
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n/a |
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Name | BDBM50249522 |
Synonyms: | 2-chloro-N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(methylsulfonyl)benzamide | CHEMBL473417 | VISMODEGIB |
Type | Small organic molecule |
Emp. Form. | C19H14Cl2N2O3S |
Mol. Mass. | 421.297 |
SMILES | CS(=O)(=O)c1ccc(C(=O)Nc2ccc(Cl)c(c2)-c2ccccn2)c(Cl)c1 |
Structure |
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