Reaction Details |
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Target | Dihydroorotate dehydrogenase (quinone), mitochondrial |
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Ligand | BDBM50211709 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1636657 (CHEMBL3879555) |
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Ki | 5700±n/a nM |
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Citation | Inaoka, DK; Iida, M; Hashimoto, S; Tabuchi, T; Kuranaga, T; Balogun, EO; Honma, T; Tanaka, A; Harada, S; Nara, T; Kita, K; Inoue, M Design and synthesis of potent substrate-based inhibitors of the Trypanosoma cruzi dihydroorotate dehydrogenase. Bioorg Med Chem25:1465-1470 (2017) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Dihydroorotate dehydrogenase (quinone), mitochondrial |
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Name: | Dihydroorotate dehydrogenase (quinone), mitochondrial |
Synonyms: | DHODH | DHOdehase | Dihydroorotate dehydrogenase | Dihydroorotate dehydrogenase (DHODH) | Dihydroorotate dehydrogenase, mitochondrial | Dihydroorotate oxidase | Dihydroorotate oxidase (DHODH) | PYRD_HUMAN |
Type: | Enzyme |
Mol. Mass.: | 42881.33 |
Organism: | Homo sapiens (Human) |
Description: | Q02127 |
Residue: | 395 |
Sequence: | MAWRHLKKRAQDAVIILGGGGLLFASYLMATGDERFYAEHLMPTLQGLLDPESAHRLAVR
FTSLGLLPRARFQDSDMLEVRVLGHKFRNPVGIAAGFDKHGEAVDGLYKMGFGFVEIGSV
TPKPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSVVEHRLRARQQKQAKLTEDGLPLGVN
LGKNKTSVDAAEDYAEGVRVLGPLADYLVVNVSSPNTAGLRSLQGKAELRRLLTKVLQER
DGLRRVHRPAVLVKIAPDLTSQDKEDIASVVKELGIDGLIVTNTTVSRPAGLQGALRSET
GGLSGKPLRDLSTQTIREMYALTQGRVPIIGVGGVSSGQDALEKIRAGASLVQLYTALTF
WGPPVVGKVKRELEALLKEQGFGGVTDAIGADHRR
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BDBM50211709 |
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n/a |
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Name | BDBM50211709 |
Synonyms: | CHEMBL3926030 |
Type | Small organic molecule |
Emp. Form. | C17H17F6N3O5 |
Mol. Mass. | 457.3244 |
SMILES | NCCO.OC(=O)c1[nH]c(=O)[nH]c(=O)c1CCc1cc(cc(c1)C(F)(F)F)C(F)(F)F |
Structure |
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