| Reaction Details |
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 | Report a problem with these data |
| Target | Lysophosphatidic acid receptor 1 |
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| Ligand | BDBM50233166 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1649796 (CHEMBL3998930) |
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| IC50 | 18000±n/a nM |
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| Citation |  Banerjee, S; Norman, DD; Lee, SC; Parrill, AL; Pham, TC; Baker, DL; Tigyi, GJ; Miller, DD Highly Potent Non-Carboxylic Acid Autotaxin Inhibitors Reduce Melanoma Metastasis and Chemotherapeutic Resistance of Breast Cancer Stem Cells. J Med Chem60:1309-1324 (2017) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Lysophosphatidic acid receptor 1 |
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| Name: | Lysophosphatidic acid receptor 1 |
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| Synonyms: | EDG2 | LPA receptor 1 | LPA-1 | LPA1 | LPAR1 | LPAR1_HUMAN | Lysophosphatidic acid receptor 1 (LPA1) | Lysophosphatidic acid receptor Edg-2 |
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| Type: | Enzyme |
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| Mol. Mass.: | 41120.55 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q92633 |
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| Residue: | 364 |
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| Sequence: | MAAISTSIPVISQPQFTAMNEPQCFYNESIAFFYNRSGKHLATEWNTVSKLVMGLGITVC
IFIMLANLLVMVAIYVNRRFHFPIYYLMANLAAADFFAGLAYFYLMFNTGPNTRRLTVST
WLLRQGLIDTSLTASVANLLAIAIERHITVFRMQLHTRMSNRRVVVVIVVIWTMAIVMGA
IPSVGWNCICDIENCSNMAPLYSDSYLVFWAIFNLVTFVVMVVLYAHIFGYVRQRTMRMS
RHSSGPRRNRDTMMSLLKTVVIVLGAFIICWTPGLVLLLLDVCCPQCDVLAYEKFFLLLA
EFNSAMNPIIYSYRDKEMSATFRQILCCQRSENPTGPTEGSDRSASSLNHTILAGVHSND
HSVV
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| BDBM50233166 |
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| n/a |
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| Name | BDBM50233166 |
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| Synonyms: | CHEMBL4060128 | US11124490, Compound 3g |
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| Type | Small organic molecule |
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| Emp. Form. | C17H13Cl4FN2O4S |
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| Mol. Mass. | 502.172 |
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| SMILES | Fc1c(Cl)cc(NC(=O)c2cc(c(Cl)cc2Cl)S(=O)(=O)N2CCOCC2)cc1Cl |
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| Structure | 
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