| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Poly [ADP-ribose] polymerase 2 |
|---|
| Ligand | BDBM185814 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | Biochemical Assay |
|---|
| IC50 | >19000±n/a nM |
|---|
| Citation |  Chen, CH; Chin, DN; DiPietro, LV; Fan, J; Palermo, MG; Shultz, MD; Toure, B 4-piperidinyl compounds for use as tankyrase inhibitors US Patent US Patent
|
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Poly [ADP-ribose] polymerase 2 |
|---|
| Name: | Poly [ADP-ribose] polymerase 2 |
|---|
| Synonyms: | (ARTD2 or PARP2) | ADPRT2 | ADPRTL2 | PARP2 | PARP2_HUMAN | Poly [ADP-ribose] polymerase 2 (PARP-2) | Poly [ADP-ribose] polymerase 2 (PARP2) |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 66225.70 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Q9UGN5 |
|---|
| Residue: | 583 |
|---|
| Sequence: | MAARRRRSTGGGRARALNESKRVNNGNTAPEDSSPAKKTRRCQRQESKKMPVAGGKANKD
RTEDKQDGMPGRSWASKRVSESVKALLLKGKAPVDPECTAKVGKAHVYCEGNDVYDVMLN
QTNLQFNNNKYYLIQLLEDDAQRNFSVWMRWGRVGKMGQHSLVACSGNLNKAKEIFQKKF
LDKTKNNWEDREKFEKVPGKYDMLQMDYATNTQDEEETKKEESLKSPLKPESQLDLRVQE
LIKLICNVQAMEEMMMEMKYNTKKAPLGKLTVAQIKAGYQSLKKIEDCIRAGQHGRALME
ACNEFYTRIPHDFGLRTPPLIRTQKELSEKIQLLEALGDIEIAIKLVKTELQSPEHPLDQ
HYRNLHCALRPLDHESYEFKVISQYLQSTHAPTHSDYTMTLLDLFEVEKDGEKEAFREDL
HNRMLLWHGSRMSNWVGILSHGLRIAPPEAPITGYMFGKGIYFADMSSKSANYCFASRLK
NTGLLLLSEVALGQCNELLEANPKAEGLLQGKHSTKGLGKMAPSSAHFVTLNGSTVPLGP
ASDTGILNPDGYTLNYNEYIVYNPNQVRMRYLLKVQFNFLQLW
|
|
|
|---|
| BDBM185814 |
|---|
| n/a |
|---|
| Name | BDBM185814 |
|---|
| Synonyms: | US9163003, 26 | USRE46942, Example 26 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C24H30N4O4 |
|---|
| Mol. Mass. | 438.5194 |
|---|
| SMILES | COc1ccc(cc1)C(=O)C1CCN(CC1)C1CCN(Cc2nc(C)c(C)c(=O)[nH]2)C1=O |
|---|
| Structure | 
|
|---|
Search and Browse
