| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Coagulation factor XI |
|---|
| Ligand | BDBM286001 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | In Vitro Assay for FXIa |
|---|
| pH | 7.4±n/a |
|---|
| Ki | 336±n/a nM |
|---|
| Comments | extracted |
|---|
| Citation |  Shi, J; Ewing, WR; Nielsen, L; Hu, Z; Quan, ML Diamide macrocycles that are FXIa inhibitors US Patent US10081623 Publication Date 9/25/2018 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Coagulation factor XI |
|---|
| Name: | Coagulation factor XI |
|---|
| Synonyms: | Coagulation factor XIa | Coagulation factor XIa heavy chain | Coagulation factor XIa light chain | F11 | FA11_HUMAN | FXI | Factor XIa | Factor XIa (fXIa) | PTA | Plasma thromboplastin antecedent |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 70130.58 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P03951 |
|---|
| Residue: | 625 |
|---|
| Sequence: | MIFLYQVVHFILFTSVSGECVTQLLKDTCFEGGDITTVFTPSAKYCQVVCTYHPRCLLFT
FTAESPSEDPTRWFTCVLKDSVTETLPRVNRTAAISGYSFKQCSHQISACNKDIYVDLDM
KGINYNSSVAKSAQECQERCTDDVHCHFFTYATRQFPSLEHRNICLLKHTQTGTPTRITK
LDKVVSGFSLKSCALSNLACIRDIFPNTVFADSNIDSVMAPDAFVCGRICTHHPGCLFFT
FFSQEWPKESQRNLCLLKTSESGLPSTRIKKSKALSGFSLQSCRHSIPVFCHSSFYHDTD
FLGEELDIVAAKSHEACQKLCTNAVRCQFFTYTPAQASCNEGKGKCYLKLSSNGSPTKIL
HGRGGISGYTLRLCKMDNECTTKIKPRIVGGTASVRGEWPWQVTLHTTSPTQRHLCGGSI
IGNQWILTAAHCFYGVESPKILRVYSGILNQSEIKEDTSFFGVQEIIIHDQYKMAESGYD
IALLKLETTVNYTDSQRPICLPSKGDRNVIYTDCWVTGWGYRKLRDKIQNTLQKAKIPLV
TNEECQKRYRGHKITHKMICAGYREGGKDACKGDSGGPLSCKHNEVWHLVGITSWGEGCA
QRERPGVYTNVVEYVDWILEKTQAV
|
|
|
|---|
| BDBM286001 |
|---|
| n/a |
|---|
| Name | BDBM286001 |
|---|
| Synonyms: | US10081623, Example 14 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C27H31ClN8O5 |
|---|
| Mol. Mass. | 583.039 |
|---|
| SMILES | COC(=O)Nc1ccc2c(NC(=O)C[C@H](C)CCC[C@@H](NC2=O)C(=O)NCCc2cc(Cl)ccc2-n2cnnn2)c1 |r| |
|---|
| Structure | 
|
|---|
Search and Browse
