Reaction Details | |||
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Target | Poly [ADP-ribose] polymerase tankyrase-1 [1091-1325] | ||
Ligand | BDBM231072 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | Tankyrase Biochemical Assays | ||
Temperature | 298.15±n/a K | ||
IC50 | 511±n/a nM | ||
Comments | extracted | ||
Citation | Bregman, H; Buchanan, JL; Chakka, N; Dimauro, EF; Gunaydin, H; Guzman-Perez, A; Hua, Z; Huang, H; Huang, X; Martin, MW; Patel, VF Oxazolidinone compounds and derivatives thereof US Patent US9340549 Publication Date 5/17/2016 | ||
More Info.: | Get all data from this article, Assay Method | ||
Poly [ADP-ribose] polymerase tankyrase-1 [1091-1325] | |||
Name: | Poly [ADP-ribose] polymerase tankyrase-1 [1091-1325] | ||
Synonyms: | PARP5A | PARPL | TIN1 | TINF1 | TNKS | TNKS1 | TNKS1_HUMAN | Tankyrase-1 | ||
Type: | Enzyme | ||
Mol. Mass.: | 26714.90 | ||
Organism: | Homo sapiens (Human) | ||
Description: | O95271[1091-1325] | ||
Residue: | 235 | ||
Sequence: |
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BDBM231072 | |||
n/a | |||
Name | BDBM231072 | ||
Synonyms: | US9340549, 96 | ||
Type | Small organic molecule | ||
Emp. Form. | C26H28N4O3 | ||
Mol. Mass. | 444.5255 | ||
SMILES | CC1(C)OC(=O)N([C@H]1c1ccccc1)[C@H]1CC[C@H](CC1)c1c[nH]c(=O)c(c1)-c1ncccn1 |r,wU:7.8,wD:14.15,17.22,(-6.5,5.39,;-5.16,4.62,;-6.5,3.85,;-4.26,5.87,;-2.79,5.39,;-1.46,6.16,;-2.79,3.85,;-4.26,3.37,;-4.66,1.89,;-6.14,1.49,;-6.54,0,;-5.45,-1.09,;-3.97,-.69,;-3.57,.8,;-1.46,3.08,;-1.46,1.54,;-.13,.77,;1.21,1.54,;1.21,3.08,;-.13,3.85,;2.54,.77,;3.88,1.54,;5.21,.77,;5.21,-.77,;6.54,-1.54,;3.88,-1.54,;2.54,-.77,;3.88,-3.08,;2.54,-3.85,;2.54,-5.39,;3.88,-6.16,;5.21,-5.39,;5.21,-3.85,)| | ||
Structure |