| Reaction Details |
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 | Report a problem with these data |
| Target | Apoptosis regulator Bcl-2 |
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| Ligand | BDBM50384348 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Fluorescence Polarization Assay (FPA) |
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| Temperature | 298.15±n/a K |
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| IC50 | 40±n/a nM |
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| Comments | extracted |
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| Citation |  Borzilleri, RM; Cai, Z; Tebben, AJ; Perez, HL; Zhang, L; Schroeder, GM; Wei, DD Substituted sulfonamides useful as antiapoptotic Bcl inhibitors US Patent US9346795 Publication Date 5/24/2016 |
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| More Info.: | Get all data from this article, Assay Method |
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| Apoptosis regulator Bcl-2 |
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| Name: | Apoptosis regulator Bcl-2 |
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| Synonyms: | Apoptosis regulator Bcl-2 Protein | B-cell lymphoma 2 protein (Bcl-2) | BCL-2 | BCL2 | BCL2_HUMAN | Bcl-2 Protein |
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| Type: | Homodimer or heterodimer |
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| Mol. Mass.: | 26269.11 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P10415 |
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| Residue: | 239 |
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| Sequence: | MAHAGRTGYDNREIVMKYIHYKLSQRGYEWDAGDVGAAPPGAAPAPGIFSSQPGHTPHPA
ASRDPVARTSPLQTPAAPGAAAGPALSPVPPVVHLTLRQAGDDFSRRYRRDFAEMSSQLH
LTPFTARGRFATVVEELFRDGVNWGRIVAFFEFGGVMCVESVNREMSPLVDNIALWMTEY
LNRHLHTWIQDNGGWDAFVELYGPSMRPLFDFSWLSLKTLLSLALVGACITLGAYLGHK
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| BDBM50384348 |
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| n/a |
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| Name | BDBM50384348 |
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| Synonyms: | CHEMBL2031017 | US9346795, 7 |
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| Type | Small organic molecule |
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| Emp. Form. | C40H41ClIN5O5S |
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| Mol. Mass. | 866.207 |
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| SMILES | CCCCN(CCCC)C(=O)c1nn(c(C)c1Cl)-c1ccc(cc1C(=O)N1CCc2ccccc2C1)C(=O)NS(=O)(=O)c1ccc2cccc(I)c2c1 |
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| Structure | 
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