| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Egl nine homolog 1 |
|---|
| Ligand | BDBM241056 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | HIF-PH Assay |
|---|
| pH | 7.4±n/a |
|---|
| IC50 | 111450±n/a nM |
|---|
| Comments | extracted |
|---|
| Citation |  Ho, W; Zhao, H; Deng, S; Ng, D; Wright, LR; Wu, M; Zhou, X; Arend, MP; Flippin, LA 4-hydroxy-isoquinoline compounds as HIF hydroxylase inhibitors US Patent US9409892 Publication Date 8/9/2016 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Egl nine homolog 1 |
|---|
| Name: | Egl nine homolog 1 |
|---|
| Synonyms: | C1orf12 | EGLN1 | EGLN1_HUMAN | Egl nine homolog 1 (EGLN1) | Hypoxia-inducible factor prolyl hydroxylase 2 (HIF-PH2) | Hypoxia-inducible factor prolyl hydroxylase 2 (HIFPH2) | Prolyl hydroxylase domain-containing protein 2 (PHD2) |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 46035.59 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Q9GZT9 |
|---|
| Residue: | 426 |
|---|
| Sequence: | MANDSGGPGGPSPSERDRQYCELCGKMENLLRCSRCRSSFYCCKEHQRQDWKKHKLVCQG
SEGALGHGVGPHQHSGPAPPAAVPPPRAGAREPRKAAARRDNASGDAAKGKVKAKPPADP
AAAASPCRAAAGGQGSAVAAEAEPGKEEPPARSSLFQEKANLYPPSNTPGDALSPGGGLR
PNGQTKPLPALKLALEYIVPCMNKHGICVVDDFLGKETGQQIGDEVRALHDTGKFTDGQL
VSQKSDSSKDIRGDKITWIEGKEPGCETIGLLMSSMDDLIRHCNGKLGSYKINGRTKAMV
ACYPGNGTGYVRHVDNPNGDGRCVTCIYYLNKDWDAKVSGGILRIFPEGKAQFADIEPKF
DRLLFFWSDRRNPHEVQPAYATRYAITVWYFDADERARAKVKYLTGEKGVRVELNKPSDS
VGKDVF
|
|
|
|---|
| BDBM241056 |
|---|
| n/a |
|---|
| Name | BDBM241056 |
|---|
| Synonyms: | US9409892, 151 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C26H23F3N4O5 |
|---|
| Mol. Mass. | 528.4798 |
|---|
| SMILES | Cn1nc(cc1-c1nc(C(=O)NCC(C)(C)C(O)=O)c(O)c2ccc(Oc3ccccc3)cc12)C(F)(F)F |
|---|
| Structure | 
|
|---|
Search and Browse
