| Reaction Details |
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 | Report a problem with these data |
| Target | Glutathione S-transferase P/Rho-associated protein kinase 2 [5-554] |
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| Ligand | BDBM258599 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Competition Binding Assay |
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| Temperature | 298.15±n/a K |
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| IC50 | 664±n/a nM |
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| Comments | extracted |
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| Citation |  Akama, T; Jarnagin, K; Zhang, Y; Zhou, Y; Plattner, JJ; Sullivan, DC Boron-containing small molecules US Patent US9493490 Publication Date 11/15/2016 |
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| More Info.: | Get all data from this article, Assay Method |
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| |
| Glutathione S-transferase P/Rho-associated protein kinase 2 [5-554] |
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| Name: | Glutathione S-transferase P/Rho-associated protein kinase 2 [5-554] |
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| Synonyms: | GST-Rho-associated protein kinase 2 (ROCK2) |
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| Type: | Enzyme |
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| Mol. Mass.: | n/a |
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| Description: | n/a |
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| Components: | This complex has 2 components. |
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| Component 1 |
| Name: | Glutathione S-transferase P |
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| Synonyms: | FAEES3 | GST class-pi | GST3 | GSTP1 | GSTP1-1 | GSTP1_HUMAN | Glutathione S-transferase | Glutathione S-transferase (GST) | Glutathione S-transferase P | Glutathione S-transferase Pi | Glutathione transferase (GST) |
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| Type: | Enzyme |
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| Mol. Mass.: | 23353.53 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P09211 |
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| Residue: | 210 |
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| Sequence: | MPPYTVVYFPVRGRCAALRMLLADQGQSWKEEVVTVETWQEGSLKASCLYGQLPKFQDGD
LTLYQSNTILRHLGRTLGLYGKDQQEAALVDMVNDGVEDLRCKYISLIYTNYEAGKDDYV
KALPGQLKPFETLLSQNQGGKTFIVGDQISFADYNLLDLLLIHEVLAPGCLDAFPLLSAY
VGRLSARPKLKAFLASPEYVNLPINGNGKQ
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| Component 2 |
| Name: | Rho-associated protein kinase 2 [5-554] |
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| Synonyms: | KIAA0619 | ROCK2 | ROCK2_HUMAN | Rho-associated protein kinase 2 (ROCK2) |
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| Type: | Protein |
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| Mol. Mass.: | 63069.10 |
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| Organism: | Homo sapiens (Human) |
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| Description: | aa 5-554 |
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| Residue: | 550 |
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| Sequence: | PPTGKMPGAPETAPGDGAGASRQRKLEALIRDPRSPINVESLLDGLNSLVLDLDFPALRK
NKNIDNFLNRYEKIVKKIRGLQMKAEDYDVVKVIGRGAFGEVQLVRHKASQKVYAMKLLS
KFEMIKRSDSAFFWEERDIMAFANSPWVVQLFYAFQDDRYLYMVMEYMPGGDLVNLMSNY
DVPEKWAKFYTAEVVLALDAIHSMGLIHRDVKPDNMLLDKHGHLKLADFGTCMKMDETGM
VHCDTAVGTPDYISPEVLKSQGGDGFYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYS
KIMDHKNSLCFPEDAEISKHAKNLICAFLTDREVRLGRNGVEEIRQHPFFKNDQWHWDNI
RETAAPVVPELSSDIDSSNFDDIEDDKGDVETFPIPKAFVGNQLPFIGFTYYRENLLLSD
SPSCRETDSIQSRKNEESQEIQKKLYTLEEHLSNEMQAKEELEQKCKSVNTRLEKTAKEL
EEEITLRKSVESALRQLEREKALLQHKNAEYQRKADHEADKKRNLENDVNSLKDQLEDLK
KRNQNSQIST
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| BDBM258599 |
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| n/a |
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| Name | BDBM258599 |
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| Synonyms: | US9493490, Example 11 | US9493490, L | US9493490, tert-butyl 2-fluoro-3-(1-hydroxy-7-methyl-1,3-dihydrobenzo[c][1,2]oxaborol-6-yloxy)benzylcarbamate |
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| Type | Small organic molecule |
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| Emp. Form. | C20H23BFNO5 |
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| Mol. Mass. | 387.21 |
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| SMILES | Cc1c2B(O)OCc2ccc1Oc1cccc(CNC(=O)OC(C)(C)C)c1F |
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| Structure | 
|
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