Reaction Details | |||
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Target | Tyrosine-protein kinase JAK3 [512-1124] | ||
Ligand | BDBM387827 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | Enzymatic Inhibition Assay | ||
IC50 | 87.5±n/a nM | ||
Citation | ![]() | ||
More Info.: | Get all data from this article, Assay Method | ||
Tyrosine-protein kinase JAK3 [512-1124] | |||
Name: | Tyrosine-protein kinase JAK3 [512-1124] | ||
Synonyms: | JAK3 | JAK3 (aa 512-1124) | JAK3_HUMAN | ||
Type: | Protein | ||
Mol. Mass.: | 68951.94 | ||
Organism: | Homo sapiens (Human) | ||
Description: | P52333[512-1124] | ||
Residue: | 613 | ||
Sequence: |
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BDBM387827 | |||
n/a | |||
Name | BDBM387827 | ||
Synonyms: | N-(4-(Cyanomethyl)bicyclo[2.2.1]heptan-1-yl)-2-(1-((1r, 4r)-4-(cyanomethyl)cyclohexyl)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-2-yl)acetamide | US10294226, Compound Ex. 10 | US10487083, Example 10 | US10981911, Example 55 | US11059823, Example 10 | ||
Type | Small organic molecule | ||
Emp. Form. | C27H31N7O | ||
Mol. Mass. | 469.5813 | ||
SMILES | O=C(Cc1nc2cnc3[nH]ccc3c2n1[C@H]1CC[C@H](CC#N)CC1)NC12CCC(CC#N)(CC1)C2 |r,wU:18.21,wD:15.17,(-5.87,-1.63,;-5.1,-.29,;-3.56,-.29,;-2.79,-1.63,;-3.42,-3.03,;-2.27,-4.06,;-2.27,-5.6,;-.94,-6.37,;.39,-5.6,;1.86,-6.08,;2.76,-4.83,;1.86,-3.59,;.39,-4.06,;-.94,-3.29,;-1.26,-1.79,;-.23,-.64,;1.28,-.96,;2.31,.18,;1.83,1.64,;2.86,2.79,;4.37,2.47,;5.87,2.15,;.32,1.97,;-.71,.82,;-5.87,1.04,;-5.1,2.37,;-3.56,2.37,;-2.79,3.71,;-3.56,5.04,;-2.79,6.37,;-1.25,6.37,;.29,6.37,;-5.1,5.04,;-5.87,3.71,;-4.7,3.86,)| | ||
Structure | ![]() |