Compile Data Set for Download or QSAR

Found 1268 hits with Last Name = 'smith' and Initial = 'rc'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Histamine H4 receptor (Homo sapiens (Human))	BDBM50006742 (CHEMBL3236553) Show SMILES Nc1nc(cc(n1)N1CCNCC1)C1CCCC1 Show InChI InChI=1S/C13H21N5/c14-13-16-11(10-3-1-2-4-10)9-12(17-13)18-7-5-15-6-8-18/h9-10,15H,1-8H2,(H2,14,16,17)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	1	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutical Research& Development, LLC Curated by ChEMBL					Assay Description Displacement of [3H]histamine from human recombinant histamine H4 receptor				Bioorg Med Chem Lett 24: 5489-92 (2015) Article DOI: 10.1016/j.bmcl.2014.10.013 BindingDB Entry DOI: 10.7270/Q25M67B1
					More data for this Ligand-Target Pair
Histamine H4 receptor (Homo sapiens (Human))	BDBM50036674 (CHEMBL3354820) Show SMILES Nc1cc(cc(NC2CCCC2)n1)N1CCNCC1 Show InChI InChI=1S/C14H23N5/c15-13-9-12(19-7-5-16-6-8-19)10-14(18-13)17-11-3-1-2-4-11/h9-11,16H,1-8H2,(H3,15,17,18)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	2	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutical Research& Development, LLC Curated by ChEMBL					Assay Description Displacement of [3H]histamine from human recombinant histamine H4 receptor				Bioorg Med Chem Lett 24: 5489-92 (2015) Article DOI: 10.1016/j.bmcl.2014.10.013 BindingDB Entry DOI: 10.7270/Q25M67B1
					More data for this Ligand-Target Pair
Histamine H4 receptor (Homo sapiens (Human))	BDBM315434 (US10172856, Example 86) Show SMILES CC(C)Oc1cc(Br)ccc1N(C(C)C)c1ccnc(N)n1 Show InChI InChI=1S/C16H21BrN4O/c1-10(2)21(15-7-8-19-16(18)20-15)13-6-5-12(17)9-14(13)22-11(3)4/h5-11H,1-4H3,(H2,18,19,20)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description Receptor binding was assessed using isolated plasma membranes from SKNMC neuroblastoma cell lines stably expressing recombinant human H4 receptor. To...				US Patent US10172856 (2019) BindingDB Entry DOI: 10.7270/Q2BV7JQ1
					More data for this Ligand-Target Pair
Histamine H4 receptor (Homo sapiens (Human))	BDBM50343019 ((R)-N2-isopropyl-4-(3-(methylamino)pyrrolidin-1-yl...) Show SMILES CN[C@@H]1CCN(C1)c1cc(N)nc(NC(C)C)c1 |r| Show InChI InChI=1S/C13H23N5/c1-9(2)16-13-7-11(6-12(14)17-13)18-5-4-10(8-18)15-3/h6-7,9-10,15H,4-5,8H2,1-3H3,(H3,14,16,17)/t10-/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	3.10	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutical Research& Development, LLC Curated by ChEMBL					Assay Description Displacement of [3H]histamine from human recombinant histamine H4 receptor				Bioorg Med Chem Lett 24: 5489-92 (2015) Article DOI: 10.1016/j.bmcl.2014.10.013 BindingDB Entry DOI: 10.7270/Q25M67B1
					More data for this Ligand-Target Pair
Thymidylate synthase (Mus musculus)	BDBM18771 ((2S)-2-[(4-{[(2-amino-4-oxo-1,4-dihydroquinazolin-...) Show SMILES Nc1nc2ccc(CN(CC#C)c3ccc(cc3)C(=O)N[C@@H](CCC(O)=O)C(O)=O)cc2c(=O)[nH]1 |r| Show InChI InChI=1S/C24H23N5O6/c1-2-11-29(13-14-3-8-18-17(12-14)22(33)28-24(25)27-18)16-6-4-15(5-7-16)21(32)26-19(23(34)35)9-10-20(30)31/h1,3-8,12,19H,9-11,13H2,(H,26,32)(H,30,31)(H,34,35)(H3,25,27,28,33)/t19-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	PubMed	3.40	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
ICI Pharmaceuticals Mereside Curated by ChEMBL					Assay Description Binding affinity against Thymidylate synthase was measured in vitro				J Med Chem 33: 3060-7 (1990) BindingDB Entry DOI: 10.7270/Q2ZW1JWX
					More data for this Ligand-Target Pair
Histamine H4 receptor (Homo sapiens (Human))	BDBM315466 (US10172856, Example 115) Show SMILES CCCc1cc(ccc1N(C(C)C)c1ccnc(N)n1)C(F)(F)F Show InChI InChI=1S/C17H21F3N4/c1-4-5-12-10-13(17(18,19)20)6-7-14(12)24(11(2)3)15-8-9-22-16(21)23-15/h6-11H,4-5H2,1-3H3,(H2,21,22,23)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description Receptor binding was assessed using isolated plasma membranes from SKNMC neuroblastoma cell lines stably expressing recombinant human H4 receptor. To...				US Patent US10172856 (2019) BindingDB Entry DOI: 10.7270/Q2BV7JQ1
					More data for this Ligand-Target Pair
Histamine H4 receptor (Homo sapiens (Human))	BDBM22566 (5-chloro-2-[(4-methylpiperazin-1-yl)carbonyl]-1H-i...) Show SMILES CN1CCN(CC1)C(=O)c1cc2cc(Cl)ccc2[nH]1 Show InChI InChI=1S/C14H16ClN3O/c1-17-4-6-18(7-5-17)14(19)13-9-10-8-11(15)2-3-12(10)16-13/h2-3,8-9,16H,4-7H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutical Research& Development, LLC Curated by ChEMBL					Assay Description Displacement of [3H]histamine from human recombinant histamine H4 receptor				Bioorg Med Chem Lett 24: 5489-92 (2015) Article DOI: 10.1016/j.bmcl.2014.10.013 BindingDB Entry DOI: 10.7270/Q25M67B1
					More data for this Ligand-Target Pair
Histamine H4 receptor (Homo sapiens (Human))	BDBM50036706 (CHEMBL3354815) Show SMILES CN[C@@H]1CCN(C1)c1ccnc(NC(C)C)n1 |r| Show InChI InChI=1S/C12H21N5/c1-9(2)15-12-14-6-4-11(16-12)17-7-5-10(8-17)13-3/h4,6,9-10,13H,5,7-8H2,1-3H3,(H,14,15,16)/t10-/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	6	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutical Research& Development, LLC Curated by ChEMBL					Assay Description Displacement of [3H]histamine from human recombinant histamine H4 receptor				Bioorg Med Chem Lett 24: 5489-92 (2015) Article DOI: 10.1016/j.bmcl.2014.10.013 BindingDB Entry DOI: 10.7270/Q25M67B1
					More data for this Ligand-Target Pair
Histamine H4 receptor (Homo sapiens (Human))	BDBM315348 (US10172856, Example 1) Show SMILES CCOc1cc(F)ccc1N(C(C)C)c1ccnc(N)n1 Show InChI InChI=1S/C15H19FN4O/c1-4-21-13-9-11(16)5-6-12(13)20(10(2)3)14-7-8-18-15(17)19-14/h5-10H,4H2,1-3H3,(H2,17,18,19)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	6	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description Receptor binding was assessed using isolated plasma membranes from SKNMC neuroblastoma cell lines stably expressing recombinant human H4 receptor. To...				US Patent US10172856 (2019) BindingDB Entry DOI: 10.7270/Q2BV7JQ1
					More data for this Ligand-Target Pair
Histamine H4 receptor (Homo sapiens (Human))	BDBM50343005 ((R)-N2-isopropyl-6-(3-(methylamino)pyrrolidin-1-yl...) Show SMILES CN[C@@H]1CCN(C1)c1cc(N)nc(NC(C)C)n1 |r| Show InChI InChI=1S/C12H22N6/c1-8(2)15-12-16-10(13)6-11(17-12)18-5-4-9(7-18)14-3/h6,8-9,14H,4-5,7H2,1-3H3,(H3,13,15,16,17)/t9-/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	6	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutical Research& Development, LLC Curated by ChEMBL					Assay Description Displacement of [3H]histamine from human recombinant histamine H4 receptor				Bioorg Med Chem Lett 24: 5489-92 (2015) Article DOI: 10.1016/j.bmcl.2014.10.013 BindingDB Entry DOI: 10.7270/Q25M67B1
					More data for this Ligand-Target Pair
Histamine H4 receptor (Homo sapiens (Human))	BDBM315471 (US10172856, Example 119) Show SMILES CCCc1cc(F)ccc1N(C(C)C)c1ccnc(N)n1 Show InChI InChI=1S/C16H21FN4/c1-4-5-12-10-13(17)6-7-14(12)21(11(2)3)15-8-9-19-16(18)20-15/h6-11H,4-5H2,1-3H3,(H2,18,19,20)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	7	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description Receptor binding was assessed using isolated plasma membranes from SKNMC neuroblastoma cell lines stably expressing recombinant human H4 receptor. To...				US Patent US10172856 (2019) BindingDB Entry DOI: 10.7270/Q2BV7JQ1
					More data for this Ligand-Target Pair
Histamine H4 receptor (Homo sapiens (Human))	BDBM315377 (US10172856, Example 30) Show SMILES CC(C)N(c1ccnc(N)n1)c1ccc(cc1C)S(F)(F)(F)(F)F Show InChI InChI=1S/C14H17F5N4S/c1-9(2)23(13-6-7-21-14(20)22-13)12-5-4-11(8-10(12)3)24(15,16,17,18)19/h4-9H,1-3H3,(H2,20,21,22)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	7	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description Receptor binding was assessed using isolated plasma membranes from SKNMC neuroblastoma cell lines stably expressing recombinant human H4 receptor. To...				US Patent US10172856 (2019) BindingDB Entry DOI: 10.7270/Q2BV7JQ1
					More data for this Ligand-Target Pair
Histamine H4 receptor (Homo sapiens (Human))	BDBM315386 (US10172856, Example 38) Show SMILES Cc1cc(ccc1N(Cc1cscn1)c1ccnc(N)n1)S(F)(F)(F)(F)F Show InChI InChI=1S/C15H14F5N5S2/c1-10-6-12(27(16,17,18,19)20)2-3-13(10)25(7-11-8-26-9-23-11)14-4-5-22-15(21)24-14/h2-6,8-9H,7H2,1H3,(H2,21,22,24)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	7	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description Receptor binding was assessed using isolated plasma membranes from SKNMC neuroblastoma cell lines stably expressing recombinant human H4 receptor. To...				US Patent US10172856 (2019) BindingDB Entry DOI: 10.7270/Q2BV7JQ1
					More data for this Ligand-Target Pair
Histamine H4 receptor (Homo sapiens (Human))	BDBM315465 (US10172856, Example 114) Show SMILES C\C=C\c1cc(ccc1N(C(C)C)c1ccnc(N)n1)C(F)(F)F Show InChI InChI=1S/C17H19F3N4/c1-4-5-12-10-13(17(18,19)20)6-7-14(12)24(11(2)3)15-8-9-22-16(21)23-15/h4-11H,1-3H3,(H2,21,22,23)/b5-4+	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	7	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description Receptor binding was assessed using isolated plasma membranes from SKNMC neuroblastoma cell lines stably expressing recombinant human H4 receptor. To...				US Patent US10172856 (2019) BindingDB Entry DOI: 10.7270/Q2BV7JQ1
					More data for this Ligand-Target Pair
Histamine H4 receptor (Homo sapiens (Human))	BDBM315391 (US10172856, Example 43) Show SMILES CCN(c1ccnc(N)n1)c1ccc(cc1C1CCC1)S(=O)(=O)C(F)(F)F Show InChI InChI=1S/C17H19F3N4O2S/c1-2-24(15-8-9-22-16(21)23-15)14-7-6-12(27(25,26)17(18,19)20)10-13(14)11-4-3-5-11/h6-11H,2-5H2,1H3,(H2,21,22,23)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	8	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description Receptor binding was assessed using isolated plasma membranes from SKNMC neuroblastoma cell lines stably expressing recombinant human H4 receptor. To...				US Patent US10172856 (2019) BindingDB Entry DOI: 10.7270/Q2BV7JQ1
					More data for this Ligand-Target Pair
Histamine H4 receptor (Homo sapiens (Human))	BDBM315370 (US10172856, Example 23) Show SMILES CCc1cc(ccc1N(Cc1cocn1)c1ccnc(N)n1)S(F)(F)(F)(F)F Show InChI InChI=1S/C16H16F5N5OS/c1-2-11-7-13(28(17,18,19,20)21)3-4-14(11)26(8-12-9-27-10-24-12)15-5-6-23-16(22)25-15/h3-7,9-10H,2,8H2,1H3,(H2,22,23,25)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	8	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description Receptor binding was assessed using isolated plasma membranes from SKNMC neuroblastoma cell lines stably expressing recombinant human H4 receptor. To...				US Patent US10172856 (2019) BindingDB Entry DOI: 10.7270/Q2BV7JQ1
					More data for this Ligand-Target Pair
Histamine H4 receptor (Homo sapiens (Human))	BDBM315433 (US10172856, Example 85) Show SMILES CC(C)N(c1ccnc(N)n1)c1ccc(Br)cc1OC(F)(F)F Show InChI InChI=1S/C14H14BrF3N4O/c1-8(2)22(12-5-6-20-13(19)21-12)10-4-3-9(15)7-11(10)23-14(16,17)18/h3-8H,1-2H3,(H2,19,20,21)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	8	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description Receptor binding was assessed using isolated plasma membranes from SKNMC neuroblastoma cell lines stably expressing recombinant human H4 receptor. To...				US Patent US10172856 (2019) BindingDB Entry DOI: 10.7270/Q2BV7JQ1
					More data for this Ligand-Target Pair
Histamine H4 receptor (Homo sapiens (Human))	BDBM315458 (US10172856, Example 109) Show SMILES CCc1cc(ccc1N(Cc1cocn1)c1ccnc(N)n1)C(F)(F)F Show InChI InChI=1S/C17H16F3N5O/c1-2-11-7-12(17(18,19)20)3-4-14(11)25(8-13-9-26-10-23-13)15-5-6-22-16(21)24-15/h3-7,9-10H,2,8H2,1H3,(H2,21,22,24)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	9	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description Receptor binding was assessed using isolated plasma membranes from SKNMC neuroblastoma cell lines stably expressing recombinant human H4 receptor. To...				US Patent US10172856 (2019) BindingDB Entry DOI: 10.7270/Q2BV7JQ1
					More data for this Ligand-Target Pair
Histamine H4 receptor (Homo sapiens (Human))	BDBM315353 (US10172856, Example 6) Show SMILES Nc1nccc(n1)N(Cc1cocn1)c1ccc(OC(F)(F)F)cc1C1CCC1 Show InChI InChI=1S/C19H18F3N5O2/c20-19(21,22)29-14-4-5-16(15(8-14)12-2-1-3-12)27(9-13-10-28-11-25-13)17-6-7-24-18(23)26-17/h4-8,10-12H,1-3,9H2,(H2,23,24,26)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	9	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description Receptor binding was assessed using isolated plasma membranes from SKNMC neuroblastoma cell lines stably expressing recombinant human H4 receptor. To...				US Patent US10172856 (2019) BindingDB Entry DOI: 10.7270/Q2BV7JQ1
					More data for this Ligand-Target Pair
Histamine H4 receptor (Homo sapiens (Human))	BDBM315381 (US10172856, Example 33) Show SMILES Cc1ocnc1CN(c1ccnc(N)n1)c1ccc(cc1C)S(F)(F)(F)(F)F Show InChI InChI=1S/C16H16F5N5OS/c1-10-7-12(28(17,18,19,20)21)3-4-14(10)26(8-13-11(2)27-9-24-13)15-5-6-23-16(22)25-15/h3-7,9H,8H2,1-2H3,(H2,22,23,25)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	9	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description Receptor binding was assessed using isolated plasma membranes from SKNMC neuroblastoma cell lines stably expressing recombinant human H4 receptor. To...				US Patent US10172856 (2019) BindingDB Entry DOI: 10.7270/Q2BV7JQ1
					More data for this Ligand-Target Pair
Histamine H4 receptor (Homo sapiens (Human))	BDBM315372 (US10172856, Example 25) Show SMILES CCc1cc(ccc1N(Cc1ccn[nH]1)c1ccnc(N)n1)S(F)(F)(F)(F)F Show InChI InChI=1S/C16H17F5N6S/c1-2-11-9-13(28(17,18,19,20)21)3-4-14(11)27(10-12-5-8-24-26-12)15-6-7-23-16(22)25-15/h3-9H,2,10H2,1H3,(H,24,26)(H2,22,23,25)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	9	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description Receptor binding was assessed using isolated plasma membranes from SKNMC neuroblastoma cell lines stably expressing recombinant human H4 receptor. To...				US Patent US10172856 (2019) BindingDB Entry DOI: 10.7270/Q2BV7JQ1
					More data for this Ligand-Target Pair
Histamine H4 receptor (Homo sapiens (Human))	BDBM315366 (US10172856, Example 19) Show SMILES Cc1cc(ccc1N(Cc1cocn1)c1ccnc(N)n1)S(F)(F)(F)(F)F Show InChI InChI=1S/C15H14F5N5OS/c1-10-6-12(27(16,17,18,19)20)2-3-13(10)25(7-11-8-26-9-23-11)14-4-5-22-15(21)24-14/h2-6,8-9H,7H2,1H3,(H2,21,22,24)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	9	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description Receptor binding was assessed using isolated plasma membranes from SKNMC neuroblastoma cell lines stably expressing recombinant human H4 receptor. To...				US Patent US10172856 (2019) BindingDB Entry DOI: 10.7270/Q2BV7JQ1
					More data for this Ligand-Target Pair
Thymidylate synthase (Mus musculus)	BDBM50006687 ((S)-2-(4-(((2-methyl-4-oxo-3,4-dihydroquinazolin-6...) Show SMILES Cc1nc2ccc(CN(CC#C)c3ccc(cc3)C(=O)N[C@@H](CCC(O)=O)C(O)=O)cc2c(=O)[nH]1 Show InChI InChI=1S/C25H24N4O6/c1-3-12-29(14-16-4-9-20-19(13-16)24(33)27-15(2)26-20)18-7-5-17(6-8-18)23(32)28-21(25(34)35)10-11-22(30)31/h1,4-9,13,21H,10-12,14H2,2H3,(H,28,32)(H,30,31)(H,34,35)(H,26,27,33)/t21-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	10	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
ICI Pharmaceuticals Mereside Curated by ChEMBL					Assay Description Binding affinity against Thymidylate synthase was measured in vitro				J Med Chem 33: 3060-7 (1990) BindingDB Entry DOI: 10.7270/Q2ZW1JWX
					More data for this Ligand-Target Pair
Histamine H4 receptor (Homo sapiens (Human))	BDBM315399 (US10172856, Example 51) Show SMILES CC(C)N(c1ccnc(N)n1)c1ccc(cc1C1CCC1)S(=O)(=O)C(F)(F)F Show InChI InChI=1S/C18H21F3N4O2S/c1-11(2)25(16-8-9-23-17(22)24-16)15-7-6-13(28(26,27)18(19,20)21)10-14(15)12-4-3-5-12/h6-12H,3-5H2,1-2H3,(H2,22,23,24)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	10	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description Receptor binding was assessed using isolated plasma membranes from SKNMC neuroblastoma cell lines stably expressing recombinant human H4 receptor. To...				US Patent US10172856 (2019) BindingDB Entry DOI: 10.7270/Q2BV7JQ1
					More data for this Ligand-Target Pair
Histamine H4 receptor (Homo sapiens (Human))	BDBM315470 (US10172856, Example 118) Show SMILES C\C=C\c1cc(F)ccc1N(C(C)C)c1ccnc(N)n1 Show InChI InChI=1S/C16H19FN4/c1-4-5-12-10-13(17)6-7-14(12)21(11(2)3)15-8-9-19-16(18)20-15/h4-11H,1-3H3,(H2,18,19,20)/b5-4+	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	11	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description Receptor binding was assessed using isolated plasma membranes from SKNMC neuroblastoma cell lines stably expressing recombinant human H4 receptor. To...				US Patent US10172856 (2019) BindingDB Entry DOI: 10.7270/Q2BV7JQ1
					More data for this Ligand-Target Pair
Histamine H4 receptor (Homo sapiens (Human))	BDBM50036739 (CHEMBL3354811) Show SMILES CN[C@@H]1CCN(C1)c1cc(CC(F)(F)F)nc(N)n1 |r| Show InChI InChI=1S/C11H16F3N5/c1-16-7-2-3-19(6-7)9-4-8(5-11(12,13)14)17-10(15)18-9/h4,7,16H,2-3,5-6H2,1H3,(H2,15,17,18)/t7-/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	11	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutical Research& Development, LLC Curated by ChEMBL					Assay Description Displacement of [3H]histamine from human recombinant histamine H4 receptor				Bioorg Med Chem Lett 24: 5489-92 (2015) Article DOI: 10.1016/j.bmcl.2014.10.013 BindingDB Entry DOI: 10.7270/Q25M67B1
					More data for this Ligand-Target Pair
Histamine H4 receptor (Homo sapiens (Human))	BDBM315435 (US10172856, Example 87) Show SMILES CC(C)N(c1ccnc(N)n1)c1ccc(Br)cc1OCC(F)(F)F Show InChI InChI=1S/C15H16BrF3N4O/c1-9(2)23(13-5-6-21-14(20)22-13)11-4-3-10(16)7-12(11)24-8-15(17,18)19/h3-7,9H,8H2,1-2H3,(H2,20,21,22)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	11	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description Receptor binding was assessed using isolated plasma membranes from SKNMC neuroblastoma cell lines stably expressing recombinant human H4 receptor. To...				US Patent US10172856 (2019) BindingDB Entry DOI: 10.7270/Q2BV7JQ1
					More data for this Ligand-Target Pair
Histamine H4 receptor (Homo sapiens (Human))	BDBM315351 (US10172856, Example 4) Show SMILES CCOc1cc(F)ccc1N(Cc1ccccc1)c1ccnc(N)n1 Show InChI InChI=1S/C19H19FN4O/c1-2-25-17-12-15(20)8-9-16(17)24(13-14-6-4-3-5-7-14)18-10-11-22-19(21)23-18/h3-12H,2,13H2,1H3,(H2,21,22,23)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	12	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description Receptor binding was assessed using isolated plasma membranes from SKNMC neuroblastoma cell lines stably expressing recombinant human H4 receptor. To...				US Patent US10172856 (2019) BindingDB Entry DOI: 10.7270/Q2BV7JQ1
					More data for this Ligand-Target Pair
Histamine H4 receptor (Homo sapiens (Human))	BDBM315385 (US10172856, Example 37) Show SMILES Cc1cc(ccc1N(Cc1ncccc1Cl)c1ccnc(N)n1)S(F)(F)(F)(F)F Show InChI InChI=1S/C17H15ClF5N5S/c1-11-9-12(29(19,20,21,22)23)4-5-15(11)28(16-6-8-26-17(24)27-16)10-14-13(18)3-2-7-25-14/h2-9H,10H2,1H3,(H2,24,26,27)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	12	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description Receptor binding was assessed using isolated plasma membranes from SKNMC neuroblastoma cell lines stably expressing recombinant human H4 receptor. To...				US Patent US10172856 (2019) BindingDB Entry DOI: 10.7270/Q2BV7JQ1
					More data for this Ligand-Target Pair
Histamine H4 receptor (Homo sapiens (Human))	BDBM315355 (US10172856, Example 8) Show SMILES CC(C)Cc1cc(OC(F)(F)F)ccc1N(Cc1cocn1)c1ccnc(N)n1 Show InChI InChI=1S/C19H20F3N5O2/c1-12(2)7-13-8-15(29-19(20,21)22)3-4-16(13)27(9-14-10-28-11-25-14)17-5-6-24-18(23)26-17/h3-6,8,10-12H,7,9H2,1-2H3,(H2,23,24,26)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	12	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description Receptor binding was assessed using isolated plasma membranes from SKNMC neuroblastoma cell lines stably expressing recombinant human H4 receptor. To...				US Patent US10172856 (2019) BindingDB Entry DOI: 10.7270/Q2BV7JQ1
					More data for this Ligand-Target Pair
Histamine H4 receptor (Homo sapiens (Human))	BDBM315392 (US10172856, Example 44) Show SMILES Nc1nccc(n1)N(Cc1cocn1)c1ccc(cc1C1CCC1)S(=O)(=O)C(F)(F)F Show InChI InChI=1S/C19H18F3N5O3S/c20-19(21,22)31(28,29)14-4-5-16(15(8-14)12-2-1-3-12)27(9-13-10-30-11-25-13)17-6-7-24-18(23)26-17/h4-8,10-12H,1-3,9H2,(H2,23,24,26)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	13	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description Receptor binding was assessed using isolated plasma membranes from SKNMC neuroblastoma cell lines stably expressing recombinant human H4 receptor. To...				US Patent US10172856 (2019) BindingDB Entry DOI: 10.7270/Q2BV7JQ1
					More data for this Ligand-Target Pair
Histamine H4 receptor (Homo sapiens (Human))	BDBM315387 (US10172856, Example 39) Show SMILES Cc1cc(ccc1N(Cc1n[nH]cc1F)c1ccnc(N)n1)S(F)(F)(F)(F)F Show InChI InChI=1S/C15H14F6N6S/c1-9-6-10(28(17,18,19,20)21)2-3-13(9)27(8-12-11(16)7-24-26-12)14-4-5-23-15(22)25-14/h2-7H,8H2,1H3,(H,24,26)(H2,22,23,25)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	14	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description Receptor binding was assessed using isolated plasma membranes from SKNMC neuroblastoma cell lines stably expressing recombinant human H4 receptor. To...				US Patent US10172856 (2019) BindingDB Entry DOI: 10.7270/Q2BV7JQ1
					More data for this Ligand-Target Pair
Histamine H4 receptor (Homo sapiens (Human))	BDBM315383 (US10172856, Example 35) Show SMILES Cc1cc(ccc1N(Cc1cnco1)c1ccnc(N)n1)S(F)(F)(F)(F)F Show InChI InChI=1S/C15H14F5N5OS/c1-10-6-12(27(16,17,18,19)20)2-3-13(10)25(8-11-7-22-9-26-11)14-4-5-23-15(21)24-14/h2-7,9H,8H2,1H3,(H2,21,23,24)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	14	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description Receptor binding was assessed using isolated plasma membranes from SKNMC neuroblastoma cell lines stably expressing recombinant human H4 receptor. To...				US Patent US10172856 (2019) BindingDB Entry DOI: 10.7270/Q2BV7JQ1
					More data for this Ligand-Target Pair
Histamine H4 receptor (Homo sapiens (Human))	BDBM315382 (US10172856, Example 34) Show SMILES Cc1cc(ccc1N(Cc1ccon1)c1ccnc(N)n1)S(F)(F)(F)(F)F Show InChI InChI=1S/C15H14F5N5OS/c1-10-8-12(27(16,17,18,19)20)2-3-13(10)25(9-11-5-7-26-24-11)14-4-6-22-15(21)23-14/h2-8H,9H2,1H3,(H2,21,22,23)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	14	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description Receptor binding was assessed using isolated plasma membranes from SKNMC neuroblastoma cell lines stably expressing recombinant human H4 receptor. To...				US Patent US10172856 (2019) BindingDB Entry DOI: 10.7270/Q2BV7JQ1
					More data for this Ligand-Target Pair
Histamine H4 receptor (Homo sapiens (Human))	BDBM315352 (US10172856, Example 5) Show SMILES CCCc1cc(OC(F)(F)F)ccc1N(Cc1cocn1)c1ccnc(N)n1 Show InChI InChI=1S/C18H18F3N5O2/c1-2-3-12-8-14(28-18(19,20)21)4-5-15(12)26(9-13-10-27-11-24-13)16-6-7-23-17(22)25-16/h4-8,10-11H,2-3,9H2,1H3,(H2,22,23,25)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	14	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description Receptor binding was assessed using isolated plasma membranes from SKNMC neuroblastoma cell lines stably expressing recombinant human H4 receptor. To...				US Patent US10172856 (2019) BindingDB Entry DOI: 10.7270/Q2BV7JQ1
					More data for this Ligand-Target Pair
Histamine H4 receptor (Homo sapiens (Human))	BDBM315384 (US10172856, Example 36) Show SMILES Cc1cc(ccc1N(Cc1ncco1)c1ccnc(N)n1)S(F)(F)(F)(F)F Show InChI InChI=1S/C15H14F5N5OS/c1-10-8-11(27(16,17,18,19)20)2-3-12(10)25(9-14-22-6-7-26-14)13-4-5-23-15(21)24-13/h2-8H,9H2,1H3,(H2,21,23,24)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	15	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description Receptor binding was assessed using isolated plasma membranes from SKNMC neuroblastoma cell lines stably expressing recombinant human H4 receptor. To...				US Patent US10172856 (2019) BindingDB Entry DOI: 10.7270/Q2BV7JQ1
					More data for this Ligand-Target Pair
Histamine H4 receptor (Homo sapiens (Human))	BDBM315445 (US10172856, Example 97) Show SMILES CCCc1cc(ccc1N(C(C)C)c1ccnc(N)n1)C#N Show InChI InChI=1S/C17H21N5/c1-4-5-14-10-13(11-18)6-7-15(14)22(12(2)3)16-8-9-20-17(19)21-16/h6-10,12H,4-5H2,1-3H3,(H2,19,20,21)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	15	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description Receptor binding was assessed using isolated plasma membranes from SKNMC neuroblastoma cell lines stably expressing recombinant human H4 receptor. To...				US Patent US10172856 (2019) BindingDB Entry DOI: 10.7270/Q2BV7JQ1
					More data for this Ligand-Target Pair
Histamine H4 receptor (Homo sapiens (Human))	BDBM315388 (US10172856, Example 40) Show SMILES Cc1cc(ccc1N(Cc1n[nH]cc1Cl)c1ccnc(N)n1)S(F)(F)(F)(F)F Show InChI InChI=1S/C15H14ClF5N6S/c1-9-6-10(28(17,18,19,20)21)2-3-13(9)27(8-12-11(16)7-24-26-12)14-4-5-23-15(22)25-14/h2-7H,8H2,1H3,(H,24,26)(H2,22,23,25)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	16	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description Receptor binding was assessed using isolated plasma membranes from SKNMC neuroblastoma cell lines stably expressing recombinant human H4 receptor. To...				US Patent US10172856 (2019) BindingDB Entry DOI: 10.7270/Q2BV7JQ1
					More data for this Ligand-Target Pair
Histamine H4 receptor (Homo sapiens (Human))	BDBM315389 (US10172856, Example 41) Show SMILES Cc1cc(ccc1N(Cc1cc[nH]n1)c1ccnc(N)n1)S(F)(F)(F)(F)F Show InChI InChI=1S/C15H15F5N6S/c1-10-8-12(27(16,17,18,19)20)2-3-13(10)26(9-11-4-7-23-25-11)14-5-6-22-15(21)24-14/h2-8H,9H2,1H3,(H,23,25)(H2,21,22,24)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	16	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description Receptor binding was assessed using isolated plasma membranes from SKNMC neuroblastoma cell lines stably expressing recombinant human H4 receptor. To...				US Patent US10172856 (2019) BindingDB Entry DOI: 10.7270/Q2BV7JQ1
					More data for this Ligand-Target Pair
Histamine H4 receptor (Homo sapiens (Human))	BDBM50036709 (CHEMBL3354812) Show SMILES CN[C@@H]1CCN(C1)c1cc(CCC(F)(F)F)nc(N)n1 |r| Show InChI InChI=1S/C12H18F3N5/c1-17-9-3-5-20(7-9)10-6-8(18-11(16)19-10)2-4-12(13,14)15/h6,9,17H,2-5,7H2,1H3,(H2,16,18,19)/t9-/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	16	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutical Research& Development, LLC Curated by ChEMBL					Assay Description Displacement of [3H]histamine from human recombinant histamine H4 receptor				Bioorg Med Chem Lett 24: 5489-92 (2015) Article DOI: 10.1016/j.bmcl.2014.10.013 BindingDB Entry DOI: 10.7270/Q25M67B1
					More data for this Ligand-Target Pair
Histamine H4 receptor (Homo sapiens (Human))	BDBM315410 (US10172856, Example 62) Show SMILES CC(C)Cc1cc(ccc1N(Cc1cocn1)c1ccnc(N)n1)S(=O)(=O)C(F)(F)F Show InChI InChI=1S/C19H20F3N5O3S/c1-12(2)7-13-8-15(31(28,29)19(20,21)22)3-4-16(13)27(9-14-10-30-11-25-14)17-5-6-24-18(23)26-17/h3-6,8,10-12H,7,9H2,1-2H3,(H2,23,24,26)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	16	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description Receptor binding was assessed using isolated plasma membranes from SKNMC neuroblastoma cell lines stably expressing recombinant human H4 receptor. To...				US Patent US10172856 (2019) BindingDB Entry DOI: 10.7270/Q2BV7JQ1
					More data for this Ligand-Target Pair
Histamine H4 receptor (Homo sapiens (Human))	BDBM315401 (US10172856, Example 53) Show SMILES CCc1cc(OC(F)(F)F)ccc1N(Cc1cocn1)c1ccnc(N)n1 Show InChI InChI=1S/C17H16F3N5O2/c1-2-11-7-13(27-17(18,19)20)3-4-14(11)25(8-12-9-26-10-23-12)15-5-6-22-16(21)24-15/h3-7,9-10H,2,8H2,1H3,(H2,21,22,24)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	16	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description Receptor binding was assessed using isolated plasma membranes from SKNMC neuroblastoma cell lines stably expressing recombinant human H4 receptor. To...				US Patent US10172856 (2019) BindingDB Entry DOI: 10.7270/Q2BV7JQ1
					More data for this Ligand-Target Pair
Histamine H4 receptor (Homo sapiens (Human))	BDBM315467 (US10172856, Example 116) Show SMILES CC(C)N(c1ccnc(N)n1)c1ccc(cc1C)C(F)(F)F Show InChI InChI=1S/C15H17F3N4/c1-9(2)22(13-6-7-20-14(19)21-13)12-5-4-11(8-10(12)3)15(16,17)18/h4-9H,1-3H3,(H2,19,20,21)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	17	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description Receptor binding was assessed using isolated plasma membranes from SKNMC neuroblastoma cell lines stably expressing recombinant human H4 receptor. To...				US Patent US10172856 (2019) BindingDB Entry DOI: 10.7270/Q2BV7JQ1
					More data for this Ligand-Target Pair
Histamine H4 receptor (Homo sapiens (Human))	BDBM50036705 (CHEMBL3354816) Show SMILES CN[C@@H]1CCN(C1)c1ccnc(NC(C)C)c1 |r| Show InChI InChI=1S/C13H22N4/c1-10(2)16-13-8-12(4-6-15-13)17-7-5-11(9-17)14-3/h4,6,8,10-11,14H,5,7,9H2,1-3H3,(H,15,16)/t11-/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	19	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutical Research& Development, LLC Curated by ChEMBL					Assay Description Displacement of [3H]histamine from human recombinant histamine H4 receptor				Bioorg Med Chem Lett 24: 5489-92 (2015) Article DOI: 10.1016/j.bmcl.2014.10.013 BindingDB Entry DOI: 10.7270/Q25M67B1
					More data for this Ligand-Target Pair
Histamine H4 receptor (Homo sapiens (Human))	BDBM315447 (US10172856, Example 99) Show SMILES C\C=C\c1cc(ccc1N(C(C)C)c1ccnc(N)n1)C#N Show InChI InChI=1S/C17H19N5/c1-4-5-14-10-13(11-18)6-7-15(14)22(12(2)3)16-8-9-20-17(19)21-16/h4-10,12H,1-3H3,(H2,19,20,21)/b5-4+	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	19	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description Receptor binding was assessed using isolated plasma membranes from SKNMC neuroblastoma cell lines stably expressing recombinant human H4 receptor. To...				US Patent US10172856 (2019) BindingDB Entry DOI: 10.7270/Q2BV7JQ1
					More data for this Ligand-Target Pair
Histamine H4 receptor (Homo sapiens (Human))	BDBM315473 (US10172856, Example 121) Show SMILES CC(C)N(c1ccnc(N)n1)c1ccc(F)cc1C(C)C Show InChI InChI=1S/C16H21FN4/c1-10(2)13-9-12(17)5-6-14(13)21(11(3)4)15-7-8-19-16(18)20-15/h5-11H,1-4H3,(H2,18,19,20)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	21	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description Receptor binding was assessed using isolated plasma membranes from SKNMC neuroblastoma cell lines stably expressing recombinant human H4 receptor. To...				US Patent US10172856 (2019) BindingDB Entry DOI: 10.7270/Q2BV7JQ1
					More data for this Ligand-Target Pair
Histamine H4 receptor (Homo sapiens (Human))	BDBM50006758 (CHEMBL3236568) Show SMILES CCc1cc(nc(N)n1)N1CC[C@H](C1)NC |r| Show InChI InChI=1S/C11H19N5/c1-3-8-6-10(15-11(12)14-8)16-5-4-9(7-16)13-2/h6,9,13H,3-5,7H2,1-2H3,(H2,12,14,15)/t9-/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	21	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutical Research& Development, LLC Curated by ChEMBL					Assay Description Displacement of [3H]histamine from human recombinant histamine H4 receptor				Bioorg Med Chem Lett 24: 5489-92 (2015) Article DOI: 10.1016/j.bmcl.2014.10.013 BindingDB Entry DOI: 10.7270/Q25M67B1
					More data for this Ligand-Target Pair
Histamine H4 receptor (Homo sapiens (Human))	BDBM315411 (US10172856, Example 63) Show SMILES CCc1cc(ccc1N(C(C)C)c1ccnc(N)n1)S(=O)(=O)C(F)(F)F Show InChI InChI=1S/C16H19F3N4O2S/c1-4-11-9-12(26(24,25)16(17,18)19)5-6-13(11)23(10(2)3)14-7-8-21-15(20)22-14/h5-10H,4H2,1-3H3,(H2,20,21,22)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	21	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description Receptor binding was assessed using isolated plasma membranes from SKNMC neuroblastoma cell lines stably expressing recombinant human H4 receptor. To...				US Patent US10172856 (2019) BindingDB Entry DOI: 10.7270/Q2BV7JQ1
					More data for this Ligand-Target Pair
Histamine H4 receptor (Homo sapiens (Human))	BDBM315380 (US10172856, Example 32) Show SMILES Cc1cc(ccc1N(Cc1ncccn1)c1ccnc(N)n1)S(F)(F)(F)(F)F Show InChI InChI=1S/C16H15F5N6S/c1-11-9-12(28(17,18,19,20)21)3-4-13(11)27(10-14-23-6-2-7-24-14)15-5-8-25-16(22)26-15/h2-9H,10H2,1H3,(H2,22,25,26)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	22	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description Receptor binding was assessed using isolated plasma membranes from SKNMC neuroblastoma cell lines stably expressing recombinant human H4 receptor. To...				US Patent US10172856 (2019) BindingDB Entry DOI: 10.7270/Q2BV7JQ1
					More data for this Ligand-Target Pair
Histamine H4 receptor (Homo sapiens (Human))	BDBM315420 (US10172856, Example 72) Show SMILES CCCN(c1ccnc(N)n1)c1ccc(cc1CC(C)C)S(C)(=O)=O Show InChI InChI=1S/C18H26N4O2S/c1-5-10-22(17-8-9-20-18(19)21-17)16-7-6-15(25(4,23)24)12-14(16)11-13(2)3/h6-9,12-13H,5,10-11H2,1-4H3,(H2,19,20,21)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	23	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description Receptor binding was assessed using isolated plasma membranes from SKNMC neuroblastoma cell lines stably expressing recombinant human H4 receptor. To...				US Patent US10172856 (2019) BindingDB Entry DOI: 10.7270/Q2BV7JQ1
					More data for this Ligand-Target Pair

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