| Reaction Details |
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 | Report a problem with these data |
| Target | Histamine H4 receptor |
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| Ligand | BDBM315411 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Binding Assay on Recombinant Human Histamine H4 Receptor |
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| Ki | 21.0±n/a nM |
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| Citation |  Bacani, GM; Chai, W; Edwards, JP; Smith, RC; Tichenor, MS; Venable, JD; Wei, J 2,4-diaminopyrimidine derivatives as histamine H4 modulators US Patent US10172856 Publication Date 1/8/2019 |
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| More Info.: | Get all data from this article, Assay Method |
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| Histamine H4 receptor |
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| Name: | Histamine H4 receptor |
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| Synonyms: | AXOR35 | G-protein coupled receptor 105 | GPCR105 | GPRv53 | HH4R | HISTAMINE H4 | HRH4 | HRH4_HUMAN | Histamine H4 receptor | Histamine H4 receptor (H4R) | Histamine receptor (H3 and H4) | Pfi-013 | SP9144 |
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| Type: | G Protein-Coupled Receptor (GPCR) |
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| Mol. Mass.: | 44517.02 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Binding assays were using CHO cells stably expressing hH4R receptors. |
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| Residue: | 390 |
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| Sequence: | MPDTNSTINLSLSTRVTLAFFMSLVAFAIMLGNALVILAFVVDKNLRHRSSYFFLNLAIS
DFFVGVISIPLYIPHTLFEWDFGKEICVFWLTTDYLLCTASVYNIVLISYDRYLSVSNAV
SYRTQHTGVLKIVTLMVAVWVLAFLVNGPMILVSESWKDEGSECEPGFFSEWYILAITSF
LEFVIPVILVAYFNMNIYWSLWKRDHLSRCQSHPGLTAVSSNICGHSFRGRLSSRRSLSA
STEVPASFHSERQRRKSSLMFSSRTKMNSNTIASKMGSFSQSDSVALHQREHVELLRARR
LAKSLAILLGVFAVCWAPYSLFTIVLSFYSSATGPKSVWYRIAFWLQWFNSFVNPLLYPL
CHKRFQKAFLKIFCIKKQPLPSQHSRSVSS
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| BDBM315411 |
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| n/a |
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| Name | BDBM315411 |
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| Synonyms: | US10172856, Example 63 |
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| Type | Small organic molecule |
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| Emp. Form. | C16H19F3N4O2S |
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| Mol. Mass. | 388.408 |
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| SMILES | CCc1cc(ccc1N(C(C)C)c1ccnc(N)n1)S(=O)(=O)C(F)(F)F |
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| Structure | 
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