Ki Summary

Reaction Details

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Target

Orexin receptor type 2

Ligand

BDBM386072

Substrate/Competitor

n/a

Meas. Tech.

Measurement of Orexin Type 2 Receptor Agonist Activity

EC50

130±n/a nM

Citation

Fujimoto, T; Rikimaru, K; Fukuda, K; Sugimoto, H; Matsumoto, T Substituted piperidine compound and use thereof US Patent US10508083 Publication Date 12/17/2019

More Info.:

Get all data from this article, Assay Method

Orexin receptor type 2

Name:

Orexin receptor type 2

Synonyms:

Type:

Protein

Mol. Mass.:

50710.53

Organism:

Homo sapiens (Human)

Description:

O43614

Residue:

444

Sequence:

MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAG
YIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETW
FFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVS
CIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMV
LAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARR
KTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAAN
PIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKL
SEQVVLTSISTLPAANGAGPLQNW

BDBM386072

n/a

Name

BDBM386072

Synonyms:

N-((2R,3S)-2-(((cis-4-(2,6- difluorophenyl)cyclohexyl)oxy)- methyl)piperidin-3- yl)methanesulfonamide | US10287305, Example 13 | US10508083, Example 13 | US11292766, Example 13

Type

Small organic molecule

Emp. Form.

C19H28F2N2O3S

Mol. Mass.

402.499

SMILES

CS(=O)(=O)N[C@H]1CCCN[C@H]1CO[C@H]1CC[C@H](CC1)c1c(F)cccc1F |r,wU:16.20,13.13,10.11,5.4,(6.67,-.39,;5.33,.38,;4.56,1.72,;6.1,1.72,;4,-.39,;4,-1.93,;5.33,-2.7,;5.33,-4.24,;4,-5.01,;2.67,-4.24,;2.67,-2.7,;1.33,-1.93,;1.33,-.39,;,.38,;-1.33,-.39,;-2.67,.38,;-2.67,1.92,;-1.33,2.69,;,1.92,;-4,2.69,;-4,4.23,;-2.67,5,;-5.33,5.01,;-6.67,4.23,;-6.67,2.69,;-5.33,1.92,;-5.33,.39,)|

Structure