Reaction Details | |||
---|---|---|---|
Report a problem with these data | |||
Target | Orexin receptor type 2 | ||
Ligand | BDBM386088 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | Measurement of Orexin Type 2 Receptor Agonist Activity | ||
EC50 | 0.110±n/a nM | ||
Citation | Fujimoto, T; Rikimaru, K; Fukuda, K; Sugimoto, H; Matsumoto, T Substituted piperidine compound and use thereof US Patent US10508083 Publication Date 12/17/2019 | ||
More Info.: | Get all data from this article, Assay Method | ||
Orexin receptor type 2 | |||
Name: | Orexin receptor type 2 | ||
Synonyms: | HCRTR2 | Hypocretin receptor type 2 | OX2R_HUMAN | Orexin receptor type 2 (OR 2) | Orexin receptor type 2 (OR-2) | Orexin receptor type 2 (OX2) | Orexin receptor type 2 (OX2R) | Orexin receptor type 2 (OxR2) | Ox-2-R | Ox2-R | ||
Type: | Protein | ||
Mol. Mass.: | 50710.53 | ||
Organism: | Homo sapiens (Human) | ||
Description: | O43614 | ||
Residue: | 444 | ||
Sequence: |
| ||
BDBM386088 | |||
n/a | |||
Name | BDBM386088 | ||
Synonyms: | (2R,3S)-N-ethyl-3- ((methylsulfonyl)amino)-2-(((cis-4- phenylcyclohexyl)oxy)methyl)- piperidine-1-carboxamide | US10287305, Example 30 | US10508083, Example 30 | US11292766, Example 30 | ||
Type | Small organic molecule | ||
Emp. Form. | C22H35N3O4S | ||
Mol. Mass. | 437.596 | ||
SMILES | CCNC(=O)N1CCC[C@H](NS(C)(=O)=O)[C@@H]1CO[C@H]1CC[C@H](CC1)c1ccccc1 |r,wU:21.25,18.18,15.16,9.9,(.93,-6.79,;1.33,-5.3,;.24,-4.21,;.64,-2.72,;-.45,-1.63,;2.12,-2.32,;3.21,-3.41,;4.7,-3.01,;5.1,-1.53,;4.01,-.44,;4.41,1.05,;5.9,1.45,;6.99,.36,;5.5,2.94,;6.99,2.54,;2.52,-.84,;1.43,.25,;-.05,-.15,;-1.14,.94,;-2.63,.54,;-3.72,1.63,;-3.32,3.12,;-1.83,3.52,;-.74,2.43,;-4.41,4.21,;-4.01,5.7,;-5.1,6.79,;-6.59,6.39,;-6.99,4.9,;-5.9,3.81,)| | ||
Structure |