| Reaction Details |
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 | Report a problem with these data |
| Target | Bromodomain-containing protein 4 [44-164] |
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| Ligand | BDBM425352 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Alphascreen Binding Assay |
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| IC50 | <1000±n/a nM |
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| Citation |  Zhang, J; Buell, J; Chan, K; Ibrahim, PN; Lin, J; Pham, P; Shi, S; Spevak, W; Wu, G; Wu, J Heterocyclic compounds and uses thereof US Patent US10519177 Publication Date 12/31/2019 |
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| More Info.: | Get all data from this article, Assay Method |
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| Bromodomain-containing protein 4 [44-164] |
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| Name: | Bromodomain-containing protein 4 [44-164] |
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| Synonyms: | BRD4 | BRD4_HUMAN | Bromodomain-containing protein 4 (aa 44-164) | HUNK1 |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 14412.06 |
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| Organism: | Homo sapiens (Human) |
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| Description: | BRD4-BD1 (44-164) |
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| Residue: | 121 |
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| Sequence: | NPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKLNLPDYYKIIKT
PMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQKINE
L
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| BDBM425352 |
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| n/a |
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| Name | BDBM425352 |
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| Synonyms: | 4-[1-[dideuterio-(3,3- difluorocyclobutyl)methyl]-3-[1-(2,2,2- trifluoroethyl)pyrazol-4-yl]pyrrolo[3,2- b]pyridin-6-yl]-3,5-dimethyl-isoxazole | US10519177, Compound P-0257 | US10519177, Compound P-0305 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H20F5N5O |
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| Mol. Mass. | 465.4191 |
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| SMILES | Cc1noc(C)c1-c1cnc2c(cn(CC3CC(F)(F)C3)c2c1)-c1cnn(CC(F)(F)F)c1 |
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| Structure | 
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