| Reaction Details |
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 | Report a problem with these data |
| Target | Tyrosine-protein kinase JAK2 [831-1132] |
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| Ligand | BDBM264185 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Enzyme Inhibition Assay |
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| IC50 | 23600±n/a nM |
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| Citation |  Astrand, AB; Grimster, NP; Kawatkar, S; Kettle, JG; Nilsson, MK; Ruston, L; Su, Q; Vasbinder, M; Winter-Holt, JJ; Woessner, RD; Chuaqui, CE; McCabe, J Compounds and methods for inhibiting JAK US Patent US10654835 Publication Date 5/19/2020 |
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| More Info.: | Get all data from this article, Assay Method |
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| Tyrosine-protein kinase JAK2 [831-1132] |
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| Name: | Tyrosine-protein kinase JAK2 [831-1132] |
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| Synonyms: | JAK2 | JAK2 (aa 831-1132) | JAK2_HUMAN | Tyrosine-protein kinase JAK2 (aa 831-1132) |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 35337.99 |
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| Organism: | Homo sapiens (Human) |
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| Description: | O60674[831-1132] |
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| Residue: | 302 |
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| Sequence: | GFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEE
HLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDH
IKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKV
KEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQ
GQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNM
AG
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| BDBM264185 |
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| n/a |
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| Name | BDBM264185 |
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| Synonyms: | (2R)-N-(3-{2-[(3- ethoxy-1-methyl-1H- pyrazol-4-yl)amino]-5- fluoropyrimidin-4-yl}- 1H-indol-7-yl)-2- (4-ethylpiperazin-1- yl)propanamide | US10167276, Example 8 | US10654835, Example 8 | US11247983, Example 8 | US9714236, 8 |
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| Type | Small organic molecule |
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| Emp. Form. | C27H34FN9O2 |
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| Mol. Mass. | 535.6164 |
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| SMILES | CCOc1nn(C)cc1Nc1ncc(F)c(n1)-c1c[nH]c2c(NC(=O)[C@@H](C)N3CCN(CC)CC3)cccc12 |r| |
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| Structure | 
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