Reaction Details |
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Target | Cytochrome P450 11B1, mitochondrial |
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Ligand | BDBM473972 |
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Substrate/Competitor | n/a |
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Meas. Tech. | Inhibition of Cortisol Synthesis |
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IC50 | >30000000±n/a nM |
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Citation | Balestra, M; Burke, J; Chen, Z; Cogan, D; Lord, J; Marshall, DR; McKibben, BP; Meyers, KM; Zhang, Y Bicyclic imidazole derivatives useful for the treatment of renal diseases, cardiovascular diseases and fibrotic diseases US Patent US10858342 Publication Date 12/8/2020 |
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More Info.: | Get all data from this article, Assay Method |
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Cytochrome P450 11B1, mitochondrial |
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Name: | Cytochrome P450 11B1, mitochondrial |
Synonyms: | C11B1_HUMAN | CYP11B1 | CYPXIB1 | Cytochrome P450 11B, mitochondrial precursor | Cytochrome P450 11B1 | Cytochrome P450 11B1 (CYP11B1) | Cytochrome P450 11B1, mitochondrial | S11BH |
Type: | Enzyme |
Mol. Mass.: | 57591.44 |
Organism: | Homo sapiens (Human) |
Description: | P15538 |
Residue: | 503 |
Sequence: | MALRAKAEVCMAVPWLSLQRAQALGTRAARVPRTVLPFEAMPRRPGNRWLRLLQIWREQG
YEDLHLEVHQTFQELGPIFRYDLGGAGMVCVMLPEDVEKLQQVDSLHPHRMSLEPWVAYR
QHRGHKCGVFLLNGPEWRFNRLRLNPEVLSPNAVQRFLPMVDAVARDFSQALKKKVLQNA
RGSLTLDVQPSIFHYTIEASNLALFGERLGLVGHSPSSASLNFLHALEVMFKSTVQLMFM
PRSLSRWTSPKVWKEHFEAWDCIFQYGDNCIQKIYQELAFSRPQQYTSIVAELLLNAELS
PDAIKANSMELTAGSVDTTVFPLLMTLFELARNPNVQQALRQESLAAAASISEHPQKATT
ELPLLRAALKETLRLYPVGLFLERVASSDLVLQNYHIPAGTLVRVFLYSLGRNPALFPRP
ERYNPQRWLDIRGSGRNFYHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHLQVETLTQED
IKMVYSFILRPSMFPLLTFRAIN
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BDBM473972 |
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n/a |
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Name | BDBM473972 |
Synonyms: | (R)-1-(3-Chloro-4-cyano- phenyl)-7-oxo-4,5,6,7- tetrahydro-1H- benzoimidazole-5-carboxylic acid methylamide | US10858342, Compound C-AEH |
Type | Small organic molecule |
Emp. Form. | C16H13ClN4O2 |
Mol. Mass. | 328.753 |
SMILES | CNC(=O)[C@@H]1Cc2ncn(c2C(=O)C1)-c1ccc(C#N)c(Cl)c1 |r| |
Structure |
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