Reaction Details |
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Target | Tyrosine-protein kinase JAK2 [831-1132] |
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Ligand | BDBM488777 |
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Substrate/Competitor | n/a |
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Meas. Tech. | Enzyme Inhibition Assay |
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IC50 | 1930±n/a nM |
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Citation | Nilsson, KM; Astrand, AB; Berggren, AI; Johansson, JR; Lepisto, MJ; Kawatkar, SP; Su, Q; Kettle, JG JAK1 selective inhibitors US Patent US10961228 Publication Date 3/30/2021 |
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More Info.: | Get all data from this article, Assay Method |
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Tyrosine-protein kinase JAK2 [831-1132] |
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Name: | Tyrosine-protein kinase JAK2 [831-1132] |
Synonyms: | JAK2 | JAK2 (aa 831-1132) | JAK2_HUMAN | Tyrosine-protein kinase JAK2 (aa 831-1132) |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 35337.99 |
Organism: | Homo sapiens (Human) |
Description: | O60674[831-1132] |
Residue: | 302 |
Sequence: | GFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEE
HLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDH
IKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKV
KEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQ
GQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNM
AG
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BDBM488777 |
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n/a |
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Name | BDBM488777 |
Synonyms: | (R)-2-((3R,5R)-3,5- dimethylpiperazin-1- yl)-N-(3-(5-fluoro-2- ((2-fluoro-3- (methylsulfonyl)phenyl) amino)pyrimidin-4- yl)-1H-indol-7-yl)-3- methoxypropanamide | US10961228, Example 33 |
Type | Small organic molecule |
Emp. Form. | C29H33F2N7O4S |
Mol. Mass. | 613.679 |
SMILES | COC[C@@H](N1C[C@@H](C)N[C@H](C)C1)C(=O)Nc1cccc2c(c[nH]c12)-c1nc(Nc2cccc(c2F)S(C)(=O)=O)ncc1F |r| |
Structure |
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