| Reaction Details |
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 | Report a problem with these data |
| Target | Ataxin-1 |
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| Ligand | BDBM511558 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Human ATX Enzyme Inhibition Assay |
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| IC50 | 1.000±n/a nM |
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| Citation |  Mattei, P; Hert, J; Hunziker, D; Rudolph, M; Schmitz, P; Di Giorgio, P; Gomme, J Heterocyclic compounds useful as dual ATX/CA inhibitors US Patent US11059794 Publication Date 7/13/2021 |
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| More Info.: | Get all data from this article, Assay Method |
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| Ataxin-1 |
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| Name: | Ataxin-1 |
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| Synonyms: | ATX1 | ATX1_HUMAN | ATXN1 | SCA1 |
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| Type: | Protein |
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| Mol. Mass.: | 86941.25 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P54253 |
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| Residue: | 815 |
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| Sequence: | MKSNQERSNECLPPKKREIPATSRSSEEKAPTLPSDNHRVEGTAWLPGNPGGRGHGGGRH
GPAGTSVELGLQQGIGLHKALSTGLDYSPPSAPRSVPVATTLPAAYATPQPGTPVSPVQY
AHLPHTFQFIGSSQYSGTYASFIPSQLIPPTANPVTSAVASAAGATTPSQRSQLEAYSTL
LANMGSLSQTPGHKAEQQQQQQQQQQQQHQHQQQQQQQQQQQQQQHLSRAPGLITPGSPP
PAQQNQYVHISSSPQNTGRTASPPAIPVHLHPHQTMIPHTLTLGPPSQVVMQYADSGSHF
VPREATKKAESSRLQQAIQAKEVLNGEMEKSRRYGAPSSADLGLGKAGGKSVPHPYESRH
VVVHPSPSDYSSRDPSGVRASVMVLPNSNTPAADLEVQQATHREASPSTLNDKSGLHLGK
PGHRSYALSPHTVIQTTHSASEPLPVGLPATAFYAGTQPPVIGYLSGQQQAITYAGSLPQ
HLVIPGTQPLLIPVGSTDMEASGAAPAIVTSSPQFAAVPHTFVTTALPKSENFNPEALVT
QAAYPAMVQAQIHLPVVQSVASPAAAPPTLPPYFMKGSIIQLANGELKKVEDLKTEDFIQ
SAEISNDLKIDSSTVERIEDSHSPGVAVIQFAVGEHRAQVSVEVLVEYPFFVFGQGWSSC
CPERTSQLFDLPCSKLSVGDVCISLTLKNLKNGSVKKGQPVDPASVLLKHSKADGLAGSR
HRYAEQENGINQGSAQMLSENGELKFPEKMGLPAAPFLTKIEPSKPAATRKRRWSAPESR
KLEKSEDEPPLTLPKPSLIPQEVKICIEGRSNVGK
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| BDBM511558 |
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| n/a |
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| Name | BDBM511558 |
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| Synonyms: | US11059794, Example 6.18 | tert-butyl 4-[2-(2-fluoro-4- sulfamoylphenyl)sulfonylethyl]- piperidine-1-carboxylate (intermediate 16)/6-(2,2,2- trifluoroethoxy)-5- (trifluoromethyl)pyridine-3- carboxylic acid (CAS-RN 1588507- 32-7) |
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| Type | Small organic molecule |
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| Emp. Form. | C22H22F7N3O6S2 |
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| Mol. Mass. | 621.545 |
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| SMILES | NS(=O)(=O)c1ccc(c(F)c1)S(=O)(=O)CCC1CCN(CC1)C(=O)c1cnc(OCC(F)(F)F)c(c1)C(F)(F)F |
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| Structure | 
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