| Reaction Details |
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 | Report a problem with these data |
| Target | DNA damage-binding protein 1/Protein cereblon |
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| Ligand | BDBM50070114 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | CRBN-DDB1 ligand-displacement AlphaScreen Assay |
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| IC50 | 268±n/a nM |
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| Citation |  Bradner, J; Buckley, D; Winter, G Methods to induce targeted protein degradation through bifunctional molecules US Patent US11059801 Publication Date 7/13/2021 |
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| More Info.: | Get all data from this article, Assay Method |
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| DNA damage-binding protein 1/Protein cereblon |
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| Name: | DNA damage-binding protein 1/Protein cereblon |
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| Synonyms: | CRBN-DDB1 | CRBN-DDB1 complex | Cereblon_DDB1 | Protein cereblon/DNA damage-binding protein 1 |
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| Type: | Enzyme |
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| Mol. Mass.: | n/a |
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| Description: | n/a |
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| Components: | This complex has 2 components. |
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| Component 1 |
| Name: | DNA damage-binding protein 1 |
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| Synonyms: | DDB p127 subunit | DDB1 | DDB1_HUMAN | DDBa | DNA damage-binding protein a | Damage-specific DNA-binding protein 1 | HBV X-associated protein 1 | UV-DDB 1 | UV-damaged DNA-binding factor | UV-damaged DNA-binding protein 1 | XAP-1 | XAP1 | XPCe | XPE-BF | XPE-binding factor | Xeroderma pigmentosum group E-complementing protein |
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| Type: | Protein |
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| Mol. Mass.: | 126936.22 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q16531 |
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| Residue: | 1140 |
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| Sequence: | MSYNYVVTAQKPTAVNGCVTGHFTSAEDLNLLIAKNTRLEIYVVTAEGLRPVKEVGMYGK
IAVMELFRPKGESKDLLFILTAKYNACILEYKQSGESIDIITRAHGNVQDRIGRPSETGI
IGIIDPECRMIGLRLYDGLFKVIPLDRDNKELKAFNIRLEELHVIDVKFLYGCQAPTICF
VYQDPQGRHVKTYEVSLREKEFNKGPWKQENVEAEASMVIAVPEPFGGAIIIGQESITYH
NGDKYLAIAPPIIKQSTIVCHNRVDPNGSRYLLGDMEGRLFMLLLEKEEQMDGTVTLKDL
RVELLGETSIAECLTYLDNGVVFVGSRLGDSQLVKLNVDSNEQGSYVVAMETFTNLGPIV
DMCVVDLERQGQGQLVTCSGAFKEGSLRIIRNGIGIHEHASIDLPGIKGLWPLRSDPNRE
TDDTLVLSFVGQTRVLMLNGEEVEETELMGFVDDQQTFFCGNVAHQQLIQITSASVRLVS
QEPKALVSEWKEPQAKNISVASCNSSQVVVAVGRALYYLQIHPQELRQISHTEMEHEVAC
LDITPLGDSNGLSPLCAIGLWTDISARILKLPSFELLHKEMLGGEIIPRSILMTTFESSH
YLLCALGDGALFYFGLNIETGLLSDRKKVTLGTQPTVLRTFRSLSTTNVFACSDRPTVIY
SSNHKLVFSNVNLKEVNYMCPLNSDGYPDSLALANNSTLTIGTIDEIQKLHIRTVPLYES
PRKICYQEVSQCFGVLSSRIEVQDTSGGTTALRPSASTQALSSSVSSSKLFSSSTAPHET
SFGEEVEVHNLLIIDQHTFEVLHAHQFLQNEYALSLVSCKLGKDPNTYFIVGTAMVYPEE
AEPKQGRIVVFQYSDGKLQTVAEKEVKGAVYSMVEFNGKLLASINSTVRLYEWTTEKELR
TECNHYNNIMALYLKTKGDFILVGDLMRSVLLLAYKPMEGNFEEIARDFNPNWMSAVEIL
DDDNFLGAENAFNLFVCQKDSAATTDEERQHLQEVGLFHLGEFVNVFCHGSLVMQNLGET
STPTQGSVLFGTVNGMIGLVTSLSESWYNLLLDMQNRLNKVIKSVGKIEHSFWRSFHTER
KTEPATGFIDGDLIESFLDISRPKMQEVVANLQYDDGSGMKREATADDLIKVVEELTRIH
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| Component 2 |
| Name: | Protein cereblon |
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| Synonyms: | CRBN | CRBN_HUMAN |
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| Type: | PROTEIN |
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| Mol. Mass.: | 50537.73 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_116917 |
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| Residue: | 442 |
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| Sequence: | MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYL
GADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTF
AVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQA
KVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSW
PRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLK
IGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETL
TVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRS
ALLPTIPDTEDEISPDKVILCL
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| BDBM50070114 |
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| n/a |
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| Name | BDBM50070114 |
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| Synonyms: | (+/-)-thalidomide | 2-(2,6-Dioxo-piperidin-3-yl)-isoindole-1,3-dione | 2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione | CHEMBL468 | K-17 | THALIDOMIDE | Thalomid | US11059801, Compound D-62 | [(R,S)-2-(2,6-dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione |
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| Type | Small organic molecule |
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| Emp. Form. | C13H10N2O4 |
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| Mol. Mass. | 258.2295 |
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| SMILES | O=C1N(C2CCC(=O)NC2=O)C(=O)c2ccccc12 |
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| Structure | 
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