| Reaction Details |
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 | Report a problem with these data |
| Target | Hepatocyte growth factor receptor [L1195V] |
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| Ligand | BDBM516920 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Enzyme Assay |
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| IC50 | 116±n/a nM |
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| Citation |  Hinklin, RJ; Allen, S; Barbour, P; Cook, A; Dahlke, J; Gaudino, J; Laird, E; McNulty, OT; Zhao, Q Pyrazolo[3,4-b]pyridine compounds as inhibitors of TAM and MET kinases US Patent US11104676 Publication Date 8/31/2021 |
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| More Info.: | Get all data from this article, Assay Method |
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| Hepatocyte growth factor receptor [L1195V] |
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| Name: | Hepatocyte growth factor receptor [L1195V] |
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| Synonyms: | Hepatocyte growth factor receptor MET (L1195V) | MET | MET_HUMAN |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 155545.71 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P08581[L1195V] |
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| Residue: | 1390 |
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| Sequence: | MKAPAVLAPGILVLLFTLVQRSNGECKEALAKSEMNVNMKYQLPNFTAETPIQNVILHEH
HIFLGATNYIYVLNEEDLQKVAEYKTGPVLEHPDCFPCQDCSSKANLSGGVWKDNINMAL
VVDTYYDDQLISCGSVNRGTCQRHVFPHNHTADIQSEVHCIFSPQIEEPSQCPDCVVSAL
GAKVLSSVKDRFINFFVGNTINSSYFPDHPLHSISVRRLKETKDGFMFLTDQSYIDVLPE
FRDSYPIKYVHAFESNNFIYFLTVQRETLDAQTFHTRIIRFCSINSGLHSYMEMPLECIL
TEKRKKRSTKKEVFNILQAAYVSKPGAQLARQIGASLNDDILFGVFAQSKPDSAEPMDRS
AMCAFPIKYVNDFFNKIVNKNNVRCLQHFYGPNHEHCFNRTLLRNSSGCEARRDEYRTEF
TTALQRVDLFMGQFSEVLLTSISTFIKGDLTIANLGTSEGRFMQVVVSRSGPSTPHVNFL
LDSHPVSPEVIVEHTLNQNGYTLVITGKKITKIPLNGLGCRHFQSCSQCLSAPPFVQCGW
CHDKCVRSEECLSGTWTQQICLPAIYKVFPNSAPLEGGTRLTICGWDFGFRRNNKFDLKK
TRVLLGNESCTLTLSESTMNTLKCTVGPAMNKHFNMSIIISNGHGTTQYSTFSYVDPVIT
SISPKYGPMAGGTLLTLTGNYLNSGNSRHISIGGKTCTLKSVSNSILECYTPAQTISTEF
AVKLKIDLANRETSIFSYREDPIVYEIHPTKSFISGGSTITGVGKNLNSVSVPRMVINVH
EAGRNFTVACQHRSNSEIICCTTPSLQQLNLQLPLKTKAFFMLDGILSKYFDLIYVHNPV
FKPFEKPVMISMGNENVLEIKGNDIDPEAVKGEVLKVGNKSCENIHLHSEAVLCTVPNDL
LKLNSELNIEWKQAISSTVLGKVIVQPDQNFTGLIAGVVSISTALLLLLGFFLWLKKRKQ
IKDLGSELVRYDARVHTPHLDRLVSARSVSPTTEMVSNESVDYRATFPEDQFPNSSQNGS
CRQVQYPLTDMSPILTSGDSDISSPLLQNTVHIDLSALNPELVQAVQHVVIGPSSLIVHF
NEVIGRGHFGCVYHGTLLDNDGKKIHCAVKSLNRITDIGEVSQFLTEGIIMKDFSHPNVL
SLLGICLRSEGSPLVVLPYMKHGDLRNFIRNETHNPTVKDLIGFGLQVAKGMKYVASKKF
VHRDLAARNCMLDEKFTVKVADFGLARDMYDKEYYSVHNKTGAKLPVKWMALESLQTQKF
TTKSDVWSFGVLLWELMTRGAPPYPDVNTFDITVYLLQGRRLLQPEYCPDPLYEVMLKCW
HPKAEMRPSFSELVSRISAIFSTFIGEHYVHVNATYVNVKCVAPYPSLLSSEDNADDEVD
TRPASFWETS
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| BDBM516920 |
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| n/a |
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| Name | BDBM516920 |
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| Synonyms: | (R)-N-(3-fluoro-4-((3- ((2- hydroxypropyl)amino)- 1H-pyrazolo[3,4- b]pyridin-4- yl)oxy)phenyl)-2-(4- fluorophenyl)-3-oxo- 2,3-dihydropyridazine- 4-carboxamide | US11104676, Example 5 |
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| Type | Small organic molecule |
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| Emp. Form. | C26H21F2N7O4 |
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| Mol. Mass. | 533.4862 |
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| SMILES | C[C@@H](O)CNc1n[nH]c2nccc(Oc3ccc(NC(=O)c4ccnn(-c5ccc(F)cc5)c4=O)cc3F)c12 |r| |
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| Structure | 
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