Ki Summary

Reaction Details

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Target

Hepatocyte growth factor receptor [D1228H]

Ligand

BDBM516967

Substrate/Competitor

n/a

Meas. Tech.

Enzyme Assay

IC50

6.10±n/a nM

Citation

Hinklin, RJ; Allen, S; Barbour, P; Cook, A; Dahlke, J; Gaudino, J; Laird, E; McNulty, OT; Zhao, Q Pyrazolo[3,4-b]pyridine compounds as inhibitors of TAM and MET kinases US Patent US11104676 Publication Date 8/31/2021

More Info.:

Get all data from this article, Assay Method

Hepatocyte growth factor receptor [D1228H]

Name:

Hepatocyte growth factor receptor [D1228H]

Synonyms:

Hepatocyte growth factor receptor (MET)(D1228H) | MET | MET_HUMAN

Type:

Enzyme Catalytic Domain

Mol. Mass.:

155583.30

Organism:

Homo sapiens (Human)

Description:

P08581[D1228H]

Residue:

1390

Sequence:

MKAPAVLAPGILVLLFTLVQRSNGECKEALAKSEMNVNMKYQLPNFTAETPIQNVILHEH
HIFLGATNYIYVLNEEDLQKVAEYKTGPVLEHPDCFPCQDCSSKANLSGGVWKDNINMAL
VVDTYYDDQLISCGSVNRGTCQRHVFPHNHTADIQSEVHCIFSPQIEEPSQCPDCVVSAL
GAKVLSSVKDRFINFFVGNTINSSYFPDHPLHSISVRRLKETKDGFMFLTDQSYIDVLPE
FRDSYPIKYVHAFESNNFIYFLTVQRETLDAQTFHTRIIRFCSINSGLHSYMEMPLECIL
TEKRKKRSTKKEVFNILQAAYVSKPGAQLARQIGASLNDDILFGVFAQSKPDSAEPMDRS
AMCAFPIKYVNDFFNKIVNKNNVRCLQHFYGPNHEHCFNRTLLRNSSGCEARRDEYRTEF
TTALQRVDLFMGQFSEVLLTSISTFIKGDLTIANLGTSEGRFMQVVVSRSGPSTPHVNFL
LDSHPVSPEVIVEHTLNQNGYTLVITGKKITKIPLNGLGCRHFQSCSQCLSAPPFVQCGW
CHDKCVRSEECLSGTWTQQICLPAIYKVFPNSAPLEGGTRLTICGWDFGFRRNNKFDLKK
TRVLLGNESCTLTLSESTMNTLKCTVGPAMNKHFNMSIIISNGHGTTQYSTFSYVDPVIT
SISPKYGPMAGGTLLTLTGNYLNSGNSRHISIGGKTCTLKSVSNSILECYTPAQTISTEF
AVKLKIDLANRETSIFSYREDPIVYEIHPTKSFISGGSTITGVGKNLNSVSVPRMVINVH
EAGRNFTVACQHRSNSEIICCTTPSLQQLNLQLPLKTKAFFMLDGILSKYFDLIYVHNPV
FKPFEKPVMISMGNENVLEIKGNDIDPEAVKGEVLKVGNKSCENIHLHSEAVLCTVPNDL
LKLNSELNIEWKQAISSTVLGKVIVQPDQNFTGLIAGVVSISTALLLLLGFFLWLKKRKQ
IKDLGSELVRYDARVHTPHLDRLVSARSVSPTTEMVSNESVDYRATFPEDQFPNSSQNGS
CRQVQYPLTDMSPILTSGDSDISSPLLQNTVHIDLSALNPELVQAVQHVVIGPSSLIVHF
NEVIGRGHFGCVYHGTLLDNDGKKIHCAVKSLNRITDIGEVSQFLTEGIIMKDFSHPNVL
SLLGICLRSEGSPLVVLPYMKHGDLRNFIRNETHNPTVKDLIGFGLQVAKGMKYLASKKF
VHRDLAARNCMLDEKFTVKVADFGLARHMYDKEYYSVHNKTGAKLPVKWMALESLQTQKF
TTKSDVWSFGVLLWELMTRGAPPYPDVNTFDITVYLLQGRRLLQPEYCPDPLYEVMLKCW
HPKAEMRPSFSELVSRISAIFSTFIGEHYVHVNATYVNVKCVAPYPSLLSSEDNADDEVD
TRPASFWETS

BDBM516967

n/a

Name

BDBM516967

Synonyms:

N-(3-fluoro-4-((3- (((1s,3s)-3- (hydroxymethyl)cyclobutyl) amino)-1H- pyrazolo[3,4-b]pyridin-4- yl)oxy)phenyl)-2-(4- fluorophenyl)-3-oxo-2,3- dihydropyridazine-4- carboxamide | US11104676, Example 37

Type

Small organic molecule

Emp. Form.

C28H23F2N7O4

Mol. Mass.

559.5235

SMILES

OC[C@H]1CC(C1)Nc1n[nH]c2nccc(Oc3ccc(NC(=O)c4ccnn(-c5ccc(F)cc5)c4=O)cc3F)c12 |r,wU:2.1,(-12.34,2.12,;-11.94,.63,;-10.45,.23,;-9.12,1,;-8.35,-.33,;-9.68,-1.1,;-6.86,-.73,;-6.46,-2.22,;-7.37,-3.47,;-6.46,-4.71,;-5,-4.23,;-3.67,-5,;-2.33,-4.23,;-2.33,-2.69,;-3.67,-1.93,;-3.67,-.38,;-2.33,.38,;-1,-.38,;.34,.38,;.34,1.93,;1.67,2.69,;3,1.93,;3,.38,;4.34,2.69,;4.34,4.23,;5.67,5,;7,4.23,;7,2.69,;8.34,1.93,;8.34,.38,;9.67,-.38,;11.01,.38,;12.34,-.38,;11.01,1.93,;9.67,2.69,;5.67,1.93,;5.67,.38,;-1,2.69,;-2.33,1.93,;-3.67,2.69,;-5,-2.69,)|

Structure