Reaction Details |
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Target | Hepatocyte growth factor receptor [1-13,15-1390] |
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Ligand | BDBM516964 |
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Substrate/Competitor | n/a |
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Meas. Tech. | Enzyme Assay |
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IC50 | 4.70±n/a nM |
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Citation | Hinklin, RJ; Allen, S; Barbour, P; Cook, A; Dahlke, J; Gaudino, J; Laird, E; McNulty, OT; Zhao, Q Pyrazolo[3,4-b]pyridine compounds as inhibitors of TAM and MET kinases US Patent US11104676 Publication Date 8/31/2021 |
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More Info.: | Get all data from this article, Assay Method |
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Hepatocyte growth factor receptor [1-13,15-1390] |
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Name: | Hepatocyte growth factor receptor [1-13,15-1390] |
Synonyms: | Hepatocyte growth factor receptor (MET)(Del14) | MET | MET_HUMAN |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 155446.58 |
Organism: | Homo sapiens (Human) |
Description: | P08581[1-13,15-1390] |
Residue: | 1389 |
Sequence: | MKAPAVLAPGILVLFTLVQRSNGECKEALAKSEMNVNMKYQLPNFTAETPIQNVILHEHH
IFLGATNYIYVLNEEDLQKVAEYKTGPVLEHPDCFPCQDCSSKANLSGGVWKDNINMALV
VDTYYDDQLISCGSVNRGTCQRHVFPHNHTADIQSEVHCIFSPQIEEPSQCPDCVVSALG
AKVLSSVKDRFINFFVGNTINSSYFPDHPLHSISVRRLKETKDGFMFLTDQSYIDVLPEF
RDSYPIKYVHAFESNNFIYFLTVQRETLDAQTFHTRIIRFCSINSGLHSYMEMPLECILT
EKRKKRSTKKEVFNILQAAYVSKPGAQLARQIGASLNDDILFGVFAQSKPDSAEPMDRSA
MCAFPIKYVNDFFNKIVNKNNVRCLQHFYGPNHEHCFNRTLLRNSSGCEARRDEYRTEFT
TALQRVDLFMGQFSEVLLTSISTFIKGDLTIANLGTSEGRFMQVVVSRSGPSTPHVNFLL
DSHPVSPEVIVEHTLNQNGYTLVITGKKITKIPLNGLGCRHFQSCSQCLSAPPFVQCGWC
HDKCVRSEECLSGTWTQQICLPAIYKVFPNSAPLEGGTRLTICGWDFGFRRNNKFDLKKT
RVLLGNESCTLTLSESTMNTLKCTVGPAMNKHFNMSIIISNGHGTTQYSTFSYVDPVITS
ISPKYGPMAGGTLLTLTGNYLNSGNSRHISIGGKTCTLKSVSNSILECYTPAQTISTEFA
VKLKIDLANRETSIFSYREDPIVYEIHPTKSFISGGSTITGVGKNLNSVSVPRMVINVHE
AGRNFTVACQHRSNSEIICCTTPSLQQLNLQLPLKTKAFFMLDGILSKYFDLIYVHNPVF
KPFEKPVMISMGNENVLEIKGNDIDPEAVKGEVLKVGNKSCENIHLHSEAVLCTVPNDLL
KLNSELNIEWKQAISSTVLGKVIVQPDQNFTGLIAGVVSISTALLLLLGFFLWLKKRKQI
KDLGSELVRYDARVHTPHLDRLVSARSVSPTTEMVSNESVDYRATFPEDQFPNSSQNGSC
RQVQYPLTDMSPILTSGDSDISSPLLQNTVHIDLSALNPELVQAVQHVVIGPSSLIVHFN
EVIGRGHFGCVYHGTLLDNDGKKIHCAVKSLNRITDIGEVSQFLTEGIIMKDFSHPNVLS
LLGICLRSEGSPLVVLPYMKHGDLRNFIRNETHNPTVKDLIGFGLQVAKGMKYLASKKFV
HRDLAARNCMLDEKFTVKVADFGLARDMYDKEYYSVHNKTGAKLPVKWMALESLQTQKFT
TKSDVWSFGVLLWELMTRGAPPYPDVNTFDITVYLLQGRRLLQPEYCPDPLYEVMLKCWH
PKAEMRPSFSELVSRISAIFSTFIGEHYVHVNATYVNVKCVAPYPSLLSSEDNADDEVDT
RPASFWETS
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BDBM516964 |
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n/a |
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Name | BDBM516964 |
Synonyms: | N-(3-fluoro-4-((3-((3- hydroxy-3-methylbutan-2- yl)amino)-1H- pyrazolo[3,4-b]pyridin-4- yl)oxy)phenyl)-2-(4- fluorophenyl)-3-oxo-2,3- dihydropyridazine-4- carboxamide | US11104676, Example 184 | US11104676, Example 185 | US11104676, Example 34 |
Type | Small organic molecule |
Emp. Form. | C28H25F2N7O4 |
Mol. Mass. | 561.5394 |
SMILES | CC(Nc1n[nH]c2nccc(Oc3ccc(NC(=O)c4ccnn(-c5ccc(F)cc5)c4=O)cc3F)c12)C(C)(C)O |
Structure |
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