| Reaction Details |
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 | Report a problem with these data |
| Target | Rap guanine nucleotide exchange factor 3 |
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| Ligand | BDBM517675 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | In Vitro Evaluation of EPAC1 Inhibition |
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| IC50 | 5100±300 nM |
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| Citation |  Zhou, J; Liu, Z; Ye, N; Mei, F; Cheng, X EPAC antagonists US Patent US11124489 Publication Date 9/21/2021 |
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| More Info.: | Get all data from this article, Assay Method |
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| Rap guanine nucleotide exchange factor 3 |
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| Name: | Rap guanine nucleotide exchange factor 3 |
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| Synonyms: | CGEF1 | EPAC | EPAC 1 | EPAC1 | Exchange factor directly activated by cAMP 1 | Exchange protein directly activated by cAMP 1 | RAPGEF3 | RPGF3_HUMAN | Rap1 guanine-nucleotide-exchange factor directly activated by cAMP | cAMP-GEFI | cAMP-regulated guanine nucleotide exchange factor I |
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| Type: | PROTEIN |
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| Mol. Mass.: | 103769.52 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_104531 |
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| Residue: | 923 |
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| Sequence: | MKVGWPGESCWQVGLAVEDSPALGAPRVGALPDVVPEGTLLNMVLRRMHRPRSCSYQLLL
EHQRPSCIQGLRWTPLTNSEESLDFSESLEQASTERVLRAGRQLHRHLLATCPNLIRDRK
YHLRLYRQCCSGRELVDGILALGLGVHSRSQVVGICQVLLDEGALCHVKHDWAFQDRDAQ
FYRFPGPEPEPVRTHEMEEELAEAVALLSQRGPDALLTVALRKPPGQRTDEELDLIFEEL
LHIKAVAHLSNSVKRELAAVLLFEPHSKAGTVLFSQGDKGTSWYIIWKGSVNVVTHGKGL
VTTLHEGDDFGQLALVNDAPRAATIILREDNCHFLRVDKQDFNRIIKDVEAKTMRLEEHG
KVVLVLERASQGAGPSRPPTPGRNRYTVMSGTPEKILELLLEAMGPDSSAHDPTETFLSD
FLLTHRVFMPSAQLCAALLHHFHVEPAGGSEQERSTYVCNKRQQILRLVSQWVALYGSML
HTDPVATSFLQKLSDLVGRDTRLSNLLREQWPERRRCHRLENGCGNASPQMKARNLPVWL
PNQDEPLPGSSCAIQVGDKVPYDICRPDHSVLTLQLPVTASVREVMAALAQEDGWTKGQV
LVKVNSAGDAIGLQPDARGVATSLGLNERLFVVNPQEVHELIPHPDQLGPTVGSAEGLDL
VSAKDLAGQLTDHDWSLFNSIHQVELIHYVLGPQHLRDVTTANLERFMRRFNELQYWVAT
ELCLCPVPGPRAQLLRKFIKLAAHLKEQKNLNSFFAVMFGLSNSAISRLAHTWERLPHKV
RKLYSALERLLDPSWNHRVYRLALAKLSPPVIPFMPLLLKDMTFIHEGNHTLVENLINFE
KMRMMARAARMLHHCRSHNPVPLSPLRSRVSHLHEDSQVARISTCSEQSLSTRSPASTWA
YVQQLKVIDNQRELSRLSRELEP
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| BDBM517675 |
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| n/a |
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| Name | BDBM517675 |
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| Synonyms: | NY0541 | US11124489, Compound 17b |
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| Type | Small organic molecule |
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| Emp. Form. | C19H12ClF3N4O2 |
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| Mol. Mass. | 420.772 |
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| SMILES | FC(F)(F)c1ccc(NNC(C#N)C(=O)c2cc(on2)-c2ccccc2)cc1Cl |
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| Structure | 
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