| Reaction Details |
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 | Report a problem with these data |
| Target | Rap guanine nucleotide exchange factor 4 |
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| Ligand | BDBM517696 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | In Vitro Evaluation of EPAC2 Inhibition |
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| IC50 | 2500±600 nM |
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| Citation |  Zhou, J; Liu, Z; Ye, N; Mei, F; Cheng, X EPAC antagonists US Patent US11124489 Publication Date 9/21/2021 |
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| More Info.: | Get all data from this article, Assay Method |
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| Rap guanine nucleotide exchange factor 4 |
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| Name: | Rap guanine nucleotide exchange factor 4 |
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| Synonyms: | CGEF2 | EPAC 2 | EPAC2 | Exchange factor directly activated by cAMP 2 | Exchange protein directly activated by cAMP 2 | RAPGEF4 | RPGF4_HUMAN | cAMP-GEFII | cAMP-regulated guanine nucleotide exchange factor II |
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| Type: | PROTEIN |
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| Mol. Mass.: | 115526.83 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1504794 |
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| Residue: | 1011 |
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| Sequence: | MVAAHAAHSSSSAEWIACLDKRPLERSSEDVDIIFTRLKEVKAFEKFHPNLLHQICLCGY
YENLEKGITLFRQGDIGTNWYAVLAGSLDVKVSETSSHQDAVTICTLGIGTAFGESILDN
TPRHATIVTRESSELLRIEQKDFKALWEKYRQYMAGLLAPPYGVMETGSNNDRIPDKENT
PLIEPHVPLRPANTITKVPSEKILRAGKILRNAILSRAPHMIRDRKYHLKTYRQCCVGTE
LVDWMMQQTPCVHSRTQAVGMWQVLLEDGVLNHVDQEHHFQDKYLFYRFLDDEHEDAPLP
TEEEKKECDEELQDTMLLLSQMGPDAHMRMILRKPPGQRTVDDLEIIYEELLHIKALSHL
STTVKRELAGVLIFESHAKGGTVLFNQGEEGTSWYIILKGSVNVVIYGKGVVCTLHEGDD
FGKLALVNDAPRAASIVLREDNCHFLRVDKEDFNRILRDVEANTVRLKEHDQDVLVLEKV
PAGNRASNQGNSQPQQKYTVMSGTPEKILEHFLETIRLEATLNEATDSVLNDFIMMHCVF
MPNTQLCPALVAHYHAQPSQGTEQEKMDYALNNKRRVIRLVLQWAAMYGDLLQEDDVSMA
FLEEFYVSVSDDARMIAALKEQLPELEKIVKQISEDAKAPQKKHKVLLQQFNTGDERAQK
RQPIRGSDEVLFKVYCMDHTYTTIRVPVATSVKEVISAVADKLGSGEGLIIVKMSSGGEK
VVLKPNDVSVFTTLTINGRLFACPREQFDSLTPLPEQEGPTVGTVGTFELMSSKDLAYQM
TIYDWELFNCVHELELIYHTFGRHNFKKTTANLDLFLRRFNEIQFWVVTEICLCSQLSKR
VQLLKKFIKIAAHCKEYKNLNSFFAIVMGLSNVAVSRLALTWEKLPSKFKKFYAEFESLM
DPSRNHRAYRLTVAKLEPPLIPFMPLLIKDMTFTHEGNKTFIDNLVNFEKMRMIANTART
VRYYRSQPFNPDAAQANKNHQDVRSYVRQLNVIDNQRTLSQMSHRLEPRRP
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| BDBM517696 |
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| n/a |
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| Name | BDBM517696 |
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| Synonyms: | US11124489, Entry 11 | ZL0475 |
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| Type | Small organic molecule |
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| Emp. Form. | C19H19Cl2N3O |
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| Mol. Mass. | 376.28 |
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| SMILES | CC(C)(C)c1ccc(cc1)C(=O)C(NNc1cc(Cl)cc(Cl)c1)C#N |
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| Structure | 
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