Search and Browse
Download
Enter Data
| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Tyrosine-protein kinase ABL1 | ||
| Ligand | BDBM524044 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | KINOMEscan competition binding assay | ||
| Kd | 0.400±n/a nM | ||
| Citation |  Lu, D; Qiao, C; Fu, B; Duddupudi, AL; Wu, Z Functionalized pyrano[2,3-D]pyrimidin-7-one derivatives and methods for their preparation and use US Patent US11136333 Publication Date 10/5/2021 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Tyrosine-protein kinase ABL1 | |||
| Name: | Tyrosine-protein kinase ABL1 | ||
| Synonyms: | ABL | ABL1 | ABL1_HUMAN | Abelson murine leukemia viral oncogene homolog 1 | JTK7 | Proto-oncogene c-Abl | Proto-oncogene tyrosine-protein kinase ABL1 | Tyrosine-protein kinase (ABL) | Tyrosine-protein kinase ABL | Tyrosine-protein kinase ABL1 (ABL) | V-abl Abelson murine leukemia viral oncogene homolog 1 | c-ABL | p150 | tyrosine-protein kinase ABL1 isoform a | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 122897.30 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P00519 | ||
| Residue: | 1130 | ||
| Sequence: |
| ||
| BDBM524044 | |||
| n/a | |||
| Name | BDBM524044 | ||
| Synonyms: | US11136333, Compound 12c | ||
| Type | Small organic molecule | ||
| Emp. Form. | C19H12Cl2N4O2 | ||
| Mol. Mass. | 399.23 | ||
| SMILES | Nc1cccc(Nc2ncc3cc(-c4c(Cl)cccc4Cl)c(=O)oc3n2)c1 |(-8,-2.69,;-6.67,-1.93,;-6.67,-.38,;-5.33,.38,;-4,-.38,;-4,-1.93,;-2.67,-2.69,;-1.33,-1.93,;-1.33,-.38,;,.38,;1.33,-.38,;2.67,.38,;4,-.38,;5.33,.38,;5.33,1.93,;4,2.69,;6.67,2.69,;8,1.93,;8,.38,;6.67,-.38,;6.67,-1.93,;4,-1.93,;5.33,-2.69,;2.67,-2.69,;1.33,-1.93,;,-2.69,;-5.33,-2.69,)| | ||
| Structure | 
| ||