Reaction Details | |||
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Target | Tyrosine-protein kinase BTK | ||
Ligand | BDBM303645 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | BTK Assay | ||
IC50 | 2.00±n/a nM | ||
Citation | Bentzien, J; Berry, AK; Bosanac, T; Burke, MJ; Disalvo, DT; Horan, JC; Liang, S; Mao, C; Mao, W; Shen, Y; Soleymanzadeh, F; Zindell, RM Heteroaromatic compounds as BTK inhibitors US Patent US10138229 Publication Date 11/27/2018 | ||
More Info.: | Get all data from this article, Assay Method | ||
Tyrosine-protein kinase BTK | |||
Name: | Tyrosine-protein kinase BTK | ||
Synonyms: | AGMX1 | ATK | Agammaglobulinaemia tyrosine kinase | Agammaglobulinemia tyrosine kinase | B cell progenitor kinase | B-cell progenitor kinase | BPK | BTK | BTK_HUMAN | Bruton tyrosine kinase | Tyrosine Kinase BTK | Tyrosine-protein kinase (BTK) | Tyrosine-protein kinase BTK (BTK) | ||
Type: | Enzyme | ||
Mol. Mass.: | 76289.95 | ||
Organism: | Homo sapiens (Human) | ||
Description: | Q06187 | ||
Residue: | 659 | ||
Sequence: |
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BDBM303645 | |||
n/a | |||
Name | BDBM303645 | ||
Synonyms: | US10138229, Example 157 | US10875852, Example 157 | ||
Type | Small organic molecule | ||
Emp. Form. | C24H27N5O3 | ||
Mol. Mass. | 433.5029 | ||
SMILES | CC#CC(=O)N1CC[C@@]2(C[C@@H](C2)n2nc(c(C(N)=O)c2N)-c2ccc(OC3CC3)cc2)C1 |r,wU:10.12,8.7,wD:8.34,(6.4,-4.89,;5.06,-5.66,;3.73,-6.43,;2.39,-7.2,;2.39,-8.74,;1.06,-6.43,;-.4,-6.9,;-1.31,-5.66,;-.4,-4.41,;-.01,-2.92,;-1.49,-2.53,;-1.89,-4.01,;-2.26,-1.19,;-1.36,.05,;-2.26,1.3,;-3.73,.82,;-5.06,1.59,;-5.06,3.13,;-6.4,.82,;-3.73,-.72,;-5.06,-1.49,;-1.86,2.79,;-.38,3.19,;.02,4.67,;-1.07,5.76,;-.67,7.25,;.82,7.65,;2.31,7.25,;1.91,8.74,;-2.55,5.36,;-2.95,3.88,;1.06,-4.89,)| | ||
Structure |