| Reaction Details |
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 | Report a problem with these data |
| Target | Nuclear factor NF-kappa-B p105 subunit |
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| Ligand | BDBM527570 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | NF-keppaB Inhibitory Activity Evaluation Test |
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| IC50 | 265±n/a nM |
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| Citation |  Aono, H; Seki, I; Imamura, M; Tanaka, T; Shirae, S; Kawashima, K; Yamazaki, Y; Yamamoto, M 6H-thieno[2,3-e][1,2,4]triazolo[3,4-c][1,2,4]triazepine derivative US Patent US11186588 Publication Date 11/30/2021 |
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| More Info.: | Get all data from this article, Assay Method |
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| Nuclear factor NF-kappa-B p105 subunit |
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| Name: | Nuclear factor NF-kappa-B p105 subunit |
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| Synonyms: | NFKB1 | NFKB1_HUMAN | Nuclear factor NF-kappa-B (NF-kB) | Nuclear factor NF-kappa-B complex | Nuclear factor NF-kappa-B p105 subunit |
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| Type: | Protein |
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| Mol. Mass.: | 105329.57 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P19838 |
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| Residue: | 968 |
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| Sequence: | MAEDDPYLGRPEQMFHLDPSLTHTIFNPEVFQPQMALPTDGPYLQILEQPKQRGFRFRYV
CEGPSHGGLPGASSEKNKKSYPQVKICNYVGPAKVIVQLVTNGKNIHLHAHSLVGKHCED
GICTVTAGPKDMVVGFANLGILHVTKKKVFETLEARMTEACIRGYNPGLLVHPDLAYLQA
EGGGDRQLGDREKELIRQAALQQTKEMDLSVVRLMFTAFLPDSTGSFTRRLEPVVSDAIY
DSKAPNASNLKIVRMDRTAGCVTGGEEIYLLCDKVQKDDIQIRFYEEEENGGVWEGFGDF
SPTDVHRQFAIVFKTPKYKDINITKPASVFVQLRRKSDLETSEPKPFLYYPEIKDKEEVQ
RKRQKLMPNFSDSFGGGSGAGAGGGGMFGSGGGGGGTGSTGPGYSFPHYGFPTYGGITFH
PGTTKSNAGMKHGTMDTESKKDPEGCDKSDDKNTVNLFGKVIETTEQDQEPSEATVGNGE
VTLTYATGTKEESAGVQDNLFLEKAMQLAKRHANALFDYAVTGDVKMLLAVQRHLTAVQD
ENGDSVLHLAIIHLHSQLVRDLLEVTSGLISDDIINMRNDLYQTPLHLAVITKQEDVVED
LLRAGADLSLLDRLGNSVLHLAAKEGHDKVLSILLKHKKAALLLDHPNGDGLNAIHLAMM
SNSLPCLLLLVAAGADVNAQEQKSGRTALHLAVEHDNISLAGCLLLEGDAHVDSTTYDGT
TPLHIAAGRGSTRLAALLKAAGADPLVENFEPLYDLDDSWENAGEDEGVVPGTTPLDMAT
SWQVFDILNGKPYEPEFTSDDLLAQGDMKQLAEDVKLQLYKLLEIPDPDKNWATLAQKLG
LGILNNAFRLSPAPSKTLMDNYEVSGGTVRELVEALRQMGYTEAIEVIQAASSPVKTTSQ
AHSLPLSPASTRQQIDELRDSDSVCDSGVETSFRKLSFTESLTSGASLLTLNKMPHDYGQ
EGPLEGKI
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| BDBM527570 |
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| n/a |
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| Name | BDBM527570 |
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| Synonyms: | US11186588, Example 29 |
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| Type | Small organic molecule |
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| Emp. Form. | C23H21N5S |
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| Mol. Mass. | 399.511 |
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| SMILES | Cc1sc-2c(c1C)C(=NN(Cc1ccccc1)c1nnc(C)n-21)c1ccccc1 |c:8| |
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| Structure | 
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