Reaction Details |
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Target | Cyclin-dependent kinase 6/G1/S-specific cyclin-D3 |
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Ligand | BDBM529895 |
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Substrate/Competitor | n/a |
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Meas. Tech. | CDK6/Cyclin D3 Mobility Shift Assay |
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Ki | 1.30±n/a nM |
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Citation | Bhattacharya, SK; Behenna, DC; Cameron, KO; Chen, P; Curto, JM; Freeman-Cook, KD; Jalaie, M; Kania, RS; Lian, Y; Nair, SK; Palmer, CL; Pettersson, MY; Rui, EY; Sammons, M; Yang, Q; Zhang, L Anti-proliferative agents for treating PAH US Patent US11203594 Publication Date 12/21/2021 |
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More Info.: | Get all data from this article, Assay Method |
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Cyclin-dependent kinase 6/G1/S-specific cyclin-D3 |
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Name: | Cyclin-dependent kinase 6/G1/S-specific cyclin-D3 |
Synonyms: | CDK6/CycD3 | CDK6/D3 | CDK6/G1/S-specific cyclin D3 | CDK6/cyclin D3 | Cyclin-dependent kinase 6 | Cyclin-dependent kinase 6/G1/S-specific cyclin D3 |
Type: | Protein |
Mol. Mass.: | n/a |
Description: | n/a |
Components: | This complex has 2 components. |
Component 1 |
Name: | Cyclin-dependent kinase 6 |
Synonyms: | CDK6 | CDK6_HUMAN | CDKN6 | Cell division protein kinase 6 | Cyclin-dependent kinase 6 (CDK 6) | Serine/threonine-protein kinase PLSTIRE |
Type: | Enzyme Subunit |
Mol. Mass.: | 36937.42 |
Organism: | Homo sapiens (Human) |
Description: | Q00534 |
Residue: | 326 |
Sequence: | MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIR
EVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTE
TIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVV
VTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGE
EDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYF
QDLERCKENLDSHLPPSQNTSELNTA
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Component 2 |
Name: | G1/S-specific cyclin-D3 |
Synonyms: | CCND3 | CCND3_HUMAN |
Type: | Enzyme |
Mol. Mass.: | 32521.90 |
Organism: | Homo sapiens (Human) |
Description: | P30281 |
Residue: | 292 |
Sequence: | MELLCCEGTRHAPRAGPDPRLLGDQRVLQSLLRLEERYVPRASYFQCVQREIKPHMRKML
AYWMLEVCEEQRCEEEVFPLAMNYLDRYLSCVPTRKAQLQLLGAVCMLLASKLRETTPLT
IEKLCIYTDHAVSPRQLRDWEVLVLGKLKWDLAAVIAHDFLAFILHRLSLPRDRQALVKK
HAQTFLALCATDYTFAMYPPSMIATGSIGAAVQGLGACSMSGDELTELLAGITGTEVDCL
RACQEQIEAALRESLREASQTSSSPAPKAPRGSSSQGPSQTSTPTDVTAIHL
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BDBM529895 |
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n/a |
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Name | BDBM529895 |
Synonyms: | US11203594, Example 5 |
Type | Small organic molecule |
Emp. Form. | C21H27N3O4 |
Mol. Mass. | 385.4568 |
SMILES | CC(=O)c1c(C)c2cnc(N[C@@H]3CCOC[C@H]3O)cc2n(C2CCCC2)c1=O |
Structure |
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