| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Beta-lactamase |
|---|
| Ligand | BDBM531027 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | Enzyme Activity: Determination of IC50 |
|---|
| IC50 | 15.9±n/a nM |
|---|
| Citation |  Pasternak, A; Dong, S; Scott, JD; Tang, H; Zhao, Z; Yang, D; Gu, X; Jiang, J; Xiao, L Metallo-beta-lactamase inhibitors and methods of use thereof US Patent US11207312 Publication Date 12/28/2021 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Beta-lactamase |
|---|
| Name: | Beta-lactamase |
|---|
| Synonyms: | Beta-lactamase | metallo-beta-lactamase IMP-1 |
|---|
| Type: | Enzyme Catalytic Domain |
|---|
| Mol. Mass.: | 27125.88 |
|---|
| Organism: | Pseudomonas aeruginosa |
|---|
| Description: | gi_27368096 |
|---|
| Residue: | 246 |
|---|
| Sequence: | MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNA
EAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELT
NELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKP
YGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKK
PSKPSN
|
|
|
|---|
| BDBM531027 |
|---|
| n/a |
|---|
| Name | BDBM531027 |
|---|
| Synonyms: | 4-(4-hydroxy-2-oxopiperidin-1- yl)-N1-((R)-pyrrolidin-3-yl)-3- (2H-tetrazol-5-yl)benzene-1,2- disulfonamide | US11207312, Example 159 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C16H22N8O6S2 |
|---|
| Mol. Mass. | 486.526 |
|---|
| SMILES | NS(=O)(=O)c1c(ccc(N2CCC(O)CC2=O)c1-c1nn[nH]n1)S(=O)(=O)N[C@@H]1CCNC1 |r| |
|---|
| Structure | 
|
|---|
Search and Browse
