| Reaction Details |
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 | Report a problem with these data |
| Target | Metallo-beta-lactamase type 2 |
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| Ligand | BDBM531067 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Enzyme Activity: Determination of IC50 |
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| IC50 | 1.69±n/a nM |
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| Citation |  Pasternak, A; Dong, S; Scott, JD; Tang, H; Zhao, Z; Yang, D; Gu, X; Jiang, J; Xiao, L Metallo-beta-lactamase inhibitors and methods of use thereof US Patent US11207312 Publication Date 12/28/2021 |
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| More Info.: | Get all data from this article, Assay Method |
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| Metallo-beta-lactamase type 2 |
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| Name: | Metallo-beta-lactamase type 2 |
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| Synonyms: | B2 metallo-beta-lactamase | BLAN1_KLEPN | Beta-lactamase NDM-1 | Beta-lactamase type II | Metallo-beta-lactamase NDM-1 | Metallo-beta-lactamase type 2 | Metallo-beta-lactamase type II | NDM-1 | New Delhi metallo-beta-lactamase-1 | blaNDM-1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 28498.15 |
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| Organism: | Klebsiella pneumoniae |
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| Description: | ChEMBL_103887 |
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| Residue: | 270 |
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| Sequence: | MELPNIMHPVAKLSTALAAALMLSGCMPGEIRPTIGQQMETGDQRFGDLVFRQLAPNVWQ
HTSYLDMPGFGAVASNGLIVRDGGRVLVVDTAWTDDQTAQILNWIKQEINLPVALAVVTH
AHQDKMGGMDALHAAGIATYANALSNQLAPQEGMVAAQHSLTFAANGWVEPATAPNFGPL
KVFYPGPGHTSDNITVGIDGTDIAFGGCLIKDSKAKSLGNLGDADTEHYAASARAFGAAF
PKASMIVMSHSAPDSRAAITHTARMADKLR
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| BDBM531067 |
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| n/a |
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| Name | BDBM531067 |
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| Synonyms: | 4-((3R,4S)-4-amino-3- fluoropiperidin-1-yl)-N1-((R)- pyrrolidin-3-yl)-3-(2H-tetrazol- 5-yl)benzene-1,2-disulfonamide | US11207312, Example 199 |
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| Type | Small organic molecule |
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| Emp. Form. | C16H24FN9O4S2 |
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| Mol. Mass. | 489.548 |
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| SMILES | N[C@H]1CCN(C[C@H]1F)c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)S(=O)(=O)N[C@@H]1CCNC1 |r| |
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| Structure | 
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