Ki Summary

Reaction Details

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Target

Interleukin-1 beta

Ligand

BDBM531280

Substrate/Competitor

n/a

Meas. Tech.

IL-1 Secretion Assa

IC50

6.80±n/a nM

Citation

Farady, C; Gommermann, N; Janser, P; Mackay, A; Mattes, H; Smith, N; Solovay, CF; Stiefl, NJ; Vangrevelinghe, E; Velcicky, J; von Matt, A NLRP3 inflammasome inhibitors US Patent US11208399 Publication Date 12/28/2021

More Info.:

Get all data from this article, Assay Method

Interleukin-1 beta

Name:

Interleukin-1 beta

Synonyms:

Type:

Cytokine

Mol. Mass.:

30734.47

Organism:

Homo sapiens (Human)

Description:

P01584

Residue:

269

Sequence:

MAEVPELASEMMAYYSGNEDDLFFEADGPKQMKCSFQDLDLCPLDGGIQLRISDHHYSKG
FRQAASVVVAMDKLRKMLVPCPQTFQENDLSTFFPFIFEEEPIFFDTWDNEAYVHDAPVR
SLNCTLRDSQQKSLVMSGPYELKALHLQGQDMEQQVVFSMSFVQGEESNDKIPVALGLKE
KNLYLSCVLKDDKPTLQLESVDPKNYPKKKMEKRFVFNKIEINNKLEFESAQFPNWYIST
SQAENMPVFLGGTKGGQDITDFTMQFVSS

BDBM531280

n/a

Name

BDBM531280

Synonyms:

US11208399, Example 40

Type

Small organic molecule

Emp. Form.

C20H25F3N4O

Mol. Mass.

394.4339

SMILES

CN1CCC[C@H](C1)Nc1nnc(c(C)c1C)-c1c(C)cc(cc1O)C(F)(F)F |r,wD:5.7,(8,-3.36,;6.67,-2.59,;6.67,-1.05,;5.33,-.28,;4,-1.05,;4,-2.59,;5.33,-3.36,;2.67,-3.36,;1.33,-2.59,;,-3.36,;-1.33,-2.59,;-1.33,-1.05,;,-.28,;,1.26,;1.33,-1.05,;2.67,-.28,;-2.67,-.28,;-2.67,1.26,;-1.33,2.03,;-4,2.03,;-5.38,1.29,;-5.33,-.28,;-4,-1.05,;-4,-2.59,;-6.72,2.06,;-8.05,2.83,;-5.95,3.39,;-7.49,.72,)|

Structure