| Reaction Details |
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 | Report a problem with these data |
| Target | Oxysterols receptor LXR-alpha |
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| Ligand | BDBM304609 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | LXR alpha/beta Radioligand Binding Assay |
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| Ki | 39.0±n/a nM |
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| Citation |  Claremon, DA; Dong, C; Fan, Y; Leftheris, K; Lotesta, SD; Singh, SB; Tice, CM; Zhao, W; Zheng, Y; Zhuang, L Piperazine derivatives as liver X receptor modulators US Patent US10144715 Publication Date 12/4/2018 |
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| More Info.: | Get all data from this article, Assay Method |
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| Oxysterols receptor LXR-alpha |
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| Name: | Oxysterols receptor LXR-alpha |
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| Synonyms: | LXRA | Liver X Receptor alpha (LXR-alpha) | Liver X receptor alpha | Liver X receptor alpha (LXRA) | Liver X receptor alpha (NR1H3) | Liver X, LXR alpha | NR1H3 | NR1H3_HUMAN | Nuclear orphan receptor LXR-alpha | Nuclear receptor subfamily 1 group H member 3 |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 50403.85 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q13133 |
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| Residue: | 447 |
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| Sequence: | MSLWLGAPVPDIPPDSAVELWKPGAQDASSQAQGGSSCILREEARMPHSAGGTAGVGLEA
AEPTALLTRAEPPSEPTEIRPQKRKKGPAPKMLGNELCSVCGDKASGFHYNVLSCEGCKG
FFRRSVIKGAHYICHSGGHCPMDTYMRRKCQECRLRKCRQAGMREECVLSEEQIRLKKLK
RQEEEQAHATSLPPRASSPPQILPQLSPEQLGMIEKLVAAQQQCNRRSFSDRLRVTPWPM
APDPHSREARQQRFAHFTELAIVSVQEIVDFAKQLPGFLQLSREDQIALLKTSAIEVMLL
ETSRRYNPGSESITFLKDFSYNREDFAKAGLQVEFINPIFEFSRAMNELQLNDAEFALLI
AISIFSADRPNVQDQLQVERLQHTYVEALHAYVSIHHPHDRLMFPRMLMKLVSLRTLSSV
HSEQVFALRLQDKKLPPLLSEIWDVHE
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| BDBM304609 |
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| n/a |
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| Name | BDBM304609 |
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| Synonyms: | (S)-1-((4,4-dimethylcyclohexyl)methyl)-4-(3-(methylsulfonyl)phenyl)-2-phenylpiperazine | US10144715, Compound 48-4 |
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| Type | Small organic molecule |
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| Emp. Form. | C26H34N2O3S |
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| Mol. Mass. | 454.625 |
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| SMILES | CC1(C)CCC(CC1)C(=O)N1CCN(C[C@@H]1c1ccccc1)c1cccc(c1)S(C)(=O)=O |r| |
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| Structure | 
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