Reaction Details |
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Target | Transient receptor potential cation channel subfamily A member 1 |
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Ligand | BDBM535098 |
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Substrate/Competitor | n/a |
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Meas. Tech. | FLIPR Assay |
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IC50 | 5.00±n/a nM |
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Citation | Chen, H; Chu, Y; Do, S; Estrada, A; Hu, B; Kolesnikov, A; Lin, X; Lyssikatos, JP; Shore, D; Verma, V; Wang, L; Wu, G; Yuen, P Substituted heterocyclic sulfonamide compounds useful as TRPA1 modulators US Patent US11236046 Publication Date 2/1/2022 |
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More Info.: | Get all data from this article, Assay Method |
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Transient receptor potential cation channel subfamily A member 1 |
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Name: | Transient receptor potential cation channel subfamily A member 1 |
Synonyms: | ANKTM1 | Ankyrin-like with transmembrane domains protein 1 | TRPA1 | TRPA1_HUMAN | Transformation-sensitive protein p120 | Transient receptor potential cation channel subfamily A member 1 (TRPA1) |
Type: | Protein |
Mol. Mass.: | 127514.20 |
Organism: | Homo sapiens (Human) |
Description: | O75762 |
Residue: | 1119 |
Sequence: | MKRSLRKMWRPGEKKEPQGVVYEDVPDDTEDFKESLKVVFEGSAYGLQNFNKQKKLKRCD
DMDTFFLHYAAAEGQIELMEKITRDSSLEVLHEMDDYGNTPLHCAVEKNQIESVKFLLSR
GANPNLRNFNMMAPLHIAVQGMNNEVMKVLLEHRTIDVNLEGENGNTAVIIACTTNNSEA
LQILLKKGAKPCKSNKWGCFPIHQAAFSGSKECMEIILRFGEEHGYSRQLHINFMNNGKA
TPLHLAVQNGDLEMIKMCLDNGAQIDPVEKGRCTAIHFAATQGATEIVKLMISSYSGSVD
IVNTTDGCHETMLHRASLFDHHELADYLISVGADINKIDSEGRSPLILATASASWNIVNL
LLSKGAQVDIKDNFGRNFLHLTVQQPYGLKNLRPEFMQMQQIKELVMDEDNDGCTPLHYA
CRQGGPGSVNNLLGFNVSIHSKSKDKKSPLHFAASYGRINTCQRLLQDISDTRLLNEGDL
HGMTPLHLAAKNGHDKVVQLLLKKGALFLSDHNGWTALHHASMGGYTQTMKVILDTNLKC
TDRLDEDGNTALHFAAREGHAKAVALLLSHNADIVLNKQQASFLHLALHNKRKEVVLTII
RSKRWDECLKIFSHNSPGNKCPITEMIEYLPECMKVLLDFCMLHSTEDKSCRDYYIEYNF
KYLQCPLEFTKKTPTQDVIYEPLTALNAMVQNNRIELLNHPVCKEYLLMKWLAYGFRAHM
MNLGSYCLGLIPMTILVVNIKPGMAFNSTGIINETSDHSEILDTTNSYLIKTCMILVFLS
SIFGYCKEAGQIFQQKRNYFMDISNVLEWIIYTTGIIFVLPLFVEIPAHLQWQCGAIAVY
FYWMNFLLYLQRFENCGIFIVMLEVILKTLLRSTVVFIFLLLAFGLSFYILLNLQDPFSS
PLLSIIQTFSMMLGDINYRESFLEPYLRNELAHPVLSFAQLVSFTIFVPIVLMNLLIGLA
VGDIAEVQKHASLKRIAMQVELHTSLEKKLPLWFLRKVDQKSTIVYPNKPRSGGMLFHIF
CFLFCTGEIRQEIPNADKSLEMEILKQKYRLKDLTFLLEKQHELIKLIIQKMEIISETED
DDSHCSFQDRFKKEQMEQRNSRWNTVLRAVKAKTHHLEP
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BDBM535098 |
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n/a |
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Name | BDBM535098 |
Synonyms: | Preparation of (2S,4R)-4-fluoro-N-((4-fluoro-4′-(trifluoromethyl)-[1,1′-biphenyl]-3-yl)methyl)-1-((4-fluorophenyl)sulfonyl)pyrrolidine-2-carboxamide | US11236046, Example 177 |
Type | Small organic molecule |
Emp. Form. | C25H20F6N2O3S |
Mol. Mass. | 542.493 |
SMILES | F[C@@H]1C[C@H](N(C1)S(=O)(=O)c1ccc(F)cc1)C(=O)NCc1cc(ccc1F)-c1ccc(cc1)C(F)(F)F |r| |
Structure |
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