| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Apoptosis regulator Bcl-2 [1-211] |
|---|
| Ligand | BDBM544483 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | Biological Assay 2 |
|---|
| IC50 | >20000±n/a nM |
|---|
| Citation |  Ferrara, SJ; Serrano-Wu, MH; Lemke, C; McKinney, D; Fitzgerald, M; Nasveschuk, C; Lazarski, K; Furst, L; Wei, G; McCarren, PR; Thede, K; Mengel, A; Christ, C; Kuhnke, J; Johannes, SA; Buchgraber, P; Klar, U; Sack, U; Kaulfuss, S; Fernandez-Montalvan, AE; Werbeck, N; Mönning, U Macrocyclic fluorine substituted indole derivatives US Patent US11286263 Publication Date 3/29/2022 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Apoptosis regulator Bcl-2 [1-211] |
|---|
| Name: | Apoptosis regulator Bcl-2 [1-211] |
|---|
| Synonyms: | BCL2 | BCL2_HUMAN |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 23308.03 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P10415[1-211] |
|---|
| Residue: | 211 |
|---|
| Sequence: | MAHAGRTGYDNREIVMKYIHYKLSQRGYEWDAGDVGAAPPGAAPAPGIFSSQPGHTPHPA
ASRDPVARTSPLQTPAAPGAAAGPALSPVPPVVHLTLRQAGDDFSRRYRRDFAEMSSQLH
LTPFTARGRFATVVEELFRDGVNWGRIVAFFEFGGVMCVESVNREMSPLVDNIALWMTEY
LNRHLHTWIQDNGGWDAFVELYGPSMRPLFD
|
|
|
|---|
| BDBM544483 |
|---|
| n/a |
|---|
| Name | BDBM544483 |
|---|
| Synonyms: | (rac)-1-(3-((2,3-dihydro-1H-inden-4-yl)oxy)propyl)-13-fluoro-11,12-dimethyl-4,5,6,7,9,11-hexahydropyrazolo[4′,3′:9,10][1]oxa[6]azacycloundecino[8,7,6-hi]indole-2-carboxylic acid | US11286263, Example 19 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C31H34FN3O4 |
|---|
| Mol. Mass. | 531.6178 |
|---|
| SMILES | Cc1c-2c(COCCCCn3c(C(O)=O)c(CCCOc4cccc5CCCc45)c4ccc(F)c-2c34)nn1C |
|---|
| Structure | 
|
|---|
Search and Browse
