| Reaction Details |
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 | Report a problem with these data |
| Target | Voltage-dependent calcium channel gamma-8 subunit |
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| Ligand | BDBM551249 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Calcium Flux Assay |
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| IC50 | 0.025±n/a nM |
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| Citation |  Ameriks, MK; Berry, CG; Chen, G; Ravula, S; Savall, BM; Swanson, DM; Wu, D; Zhang, W Azabenzimidazoles and their use as AMPA receptor modulators US Patent US11312712 Publication Date 4/26/2022 |
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| More Info.: | Get all data from this article, Assay Method |
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| Voltage-dependent calcium channel gamma-8 subunit |
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| Name: | Voltage-dependent calcium channel gamma-8 subunit |
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| Synonyms: | CACNG6 | CACNG8 | CCG8_HUMAN | Neuronal voltage-gated calcium channel gamma-8 subunit | TARP gamma-8 | Transmembrane AMPAR regulatory protein gamma-8 |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 43326.96 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q8WXS5 |
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| Residue: | 425 |
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| Sequence: | MESLKRWNEERGLWCEKGVQVLLTTVGAFAAFGLMTIAISTDYWLYTRALICNTTNLTAG
GDDGTPHRGGGGASEKKDPGGLTHSGLWRICCLEGLKRGVCVKINHFPEDTDYDHDSAEY
LLRVVRASSIFPILSAILLLLGGVCVAASRVYKSKRNIILGAGILFVAAGLSNIIGVIVY
ISANAGEPGPKRDEEKKNHYSYGWSFYFGGLSFILAEVIGVLAVNIYIERSREAHCQSRS
DLLKAGGGAGGSGGSGPSAILRLPSYRFRYRRRSRSSSRSSEPSPSRDASPGGPGGPGFA
STDISMYTLSRDPSKGSVAAGLAGAGGGGGGAVGAFGGAAGGAGGGGGGGGGAGAERDRG
GASGFLTLHNAFPKEAGGGVTVTVTGPPAPPAPAPPAPSAPAPGTLAKEAAASNTNTLNR
KTTPV
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| BDBM551249 |
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| n/a |
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| Name | BDBM551249 |
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| Synonyms: | 5-[2-Isopropyl-6-(trifluoromethyl)pyrrolo[2,3-b]pyridin-1-yl]-7-methyl-indolin-2- | US11312712, Example 367 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H18F3N3O |
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| Mol. Mass. | 373.3716 |
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| SMILES | CC(C)c1cc2ccc(nc2n1-c1cc2CC(=O)Nc2c(C)c1)C(F)(F)F |
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| Structure | 
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