| Reaction Details |
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 | Report a problem with these data |
| Target | Cytochrome P450 4F2 |
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| Ligand | BDBM558342 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Inhibition Test for Each Compound of the Present Invention Against 20-HETE Producing Enzymes (CYP4F2 and CYP4A11) |
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| IC50 | 11.0±n/a nM |
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| Citation |  Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K Pyridine compound substituted with azole US Patent US11365192 Publication Date 6/21/2022 |
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| More Info.: | Get all data from this article, Assay Method |
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| Cytochrome P450 4F2 |
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| Name: | Cytochrome P450 4F2 |
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| Synonyms: | 20-HETE synthase | 20-hydroxyeicosatetraenoic acid synthase | Arachidonic acid omega-hydroxylase | CP4F2_HUMAN | CYP4F2 | CYPIVF2 | Cytochrome P450 4F2 | Cytochrome P450-LTB-omega | Leukotriene-B(4) 20-monooxygenase 1 | Leukotriene-B(4) omega-hydroxylase 1 | Phylloquinone omega-hydroxylase CYP4F2 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 59859.32 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_10743 |
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| Residue: | 520 |
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| Sequence: | MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWF
WGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPK
DKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQL
LASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEIL
LHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFID
VLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQE
LLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIIC
LISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKV
VLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS
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| BDBM558342 |
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| n/a |
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| Name | BDBM558342 |
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| Synonyms: | US11365192, Example 42-20 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H21FN4O3 |
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| Mol. Mass. | 396.4148 |
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| SMILES | Fc1cc(OCc2cccc(CCC(=O)NC3COC3)c2)cnc1-c1ccn[nH]1 |
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| Structure | 
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