| Reaction Details |
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 | Report a problem with these data |
| Target | Cytochrome P450 4F2 |
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| Ligand | BDBM558428 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Inhibition Test for Each Compound of the Present Invention Against 20-HETE Producing Enzymes (CYP4F2 and CYP4A11) |
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| IC50 | 4.40±n/a nM |
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| Citation |  Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K Pyridine compound substituted with azole US Patent US11365192 Publication Date 6/21/2022 |
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| More Info.: | Get all data from this article, Assay Method |
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| Cytochrome P450 4F2 |
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| Name: | Cytochrome P450 4F2 |
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| Synonyms: | 20-HETE synthase | 20-hydroxyeicosatetraenoic acid synthase | Arachidonic acid omega-hydroxylase | CP4F2_HUMAN | CYP4F2 | CYPIVF2 | Cytochrome P450 4F2 | Cytochrome P450-LTB-omega | Leukotriene-B(4) 20-monooxygenase 1 | Leukotriene-B(4) omega-hydroxylase 1 | Phylloquinone omega-hydroxylase CYP4F2 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 59859.32 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_10743 |
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| Residue: | 520 |
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| Sequence: | MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWF
WGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPK
DKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQL
LASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEIL
LHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFID
VLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQE
LLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIIC
LISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKV
VLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS
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| BDBM558428 |
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| n/a |
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| Name | BDBM558428 |
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| Synonyms: | 1-[4-Hydroxy-4-[3-[[6-(1-H-pyrazol-5-yl)-3-pyridinyl]oxymethyl]phenyl]-1-piperidinyl]ethanone | US11365192, Example 52-1 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H24N4O3 |
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| Mol. Mass. | 392.451 |
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| SMILES | CC(=O)N1CCC(O)(CC1)c1cccc(COc2ccc(nc2)-c2ccn[nH]2)c1 |
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| Structure | 
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