| Reaction Details |
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 | Report a problem with these data |
| Target | Cyclin-dependent kinase 6/G1/S-specific cyclin-D1 [L188C] |
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| Ligand | BDBM370121 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | CDK6/Cyclin D1 Mobility Shift Assay |
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| Ki | 0.080±n/a nM |
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| Citation |  Behenna, DC; Chen, P; Freeman-Cook, KD; Hoffman, RL; Jalaie, M; Nagata, A; Nair, SK; Ninkovic, S; Ornelas, MA; Palmer, CL; Rui, EY CDK2/4/6 inhibitors US Patent US11396512 Publication Date 7/26/2022 |
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| More Info.: | Get all data from this article, Assay Method |
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| |
| Cyclin-dependent kinase 6/G1/S-specific cyclin-D1 [L188C] |
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| Name: | Cyclin-dependent kinase 6/G1/S-specific cyclin-D1 [L188C] |
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| Synonyms: | CDK6/Cyclin D | Cyclin-Dependent Kinase 6 (CDK6) |
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| Type: | Protein Complex |
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| Mol. Mass.: | n/a |
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| Description: | n/a |
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| Components: | This complex has 2 components. |
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| Component 1 |
| Name: | Cyclin-dependent kinase 6 |
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| Synonyms: | CDK6 | CDK6_HUMAN | CDKN6 | Cell division protein kinase 6 | Cyclin-dependent kinase 6 (CDK 6) | Serine/threonine-protein kinase PLSTIRE |
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| Type: | Enzyme Subunit |
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| Mol. Mass.: | 36937.42 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q00534 |
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| Residue: | 326 |
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| Sequence: | MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIR
EVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTE
TIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVV
VTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGE
EDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYF
QDLERCKENLDSHLPPSQNTSELNTA
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| Component 2 |
| Name: | G1/S-specific cyclin-D1 [L188C] |
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| Synonyms: | BCL1 | CCND1 | CCND1_HUMAN | Cyclin D | PRAD1 |
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| Type: | Enzyme Subunit |
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| Mol. Mass.: | 33634.57 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P24385[L188C] |
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| Residue: | 295 |
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| Sequence: | MEHQLLCCEVETIRRAYPDANLLNDRVLRAMLKAEETCAPSVSYFKCVQKEVLPSMRKIV
ATWMLEVCEEQKCEEEVFPLAMNYLDRFLSLEPVKKSRLQLLGATCMFVASKMKETIPLT
AEKLCIYTDGSIRPEELLQMELLLVNKLKWNLAAMTPHDFIEHFLSKMPEAEENKQIIRK
HAQTFVASCATDVKFISNPPSMVAAGSVVAAVQGLNLRSPNNFLSYYRLTRFLSRVIKCD
PDCLRACQEQIEALLESSLRQAQQNMDPKAAEEEEEEEEEVDLACTPTDVRDVDI
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| BDBM370121 |
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| n/a |
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| Name | BDBM370121 |
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| Synonyms: | 6-(difluoromethyl)-8-[(1R,2R)-2-hydroxy-2-methylcyclopentyl]-2-{[1-(methylsulfonyl)piperidin-4-yl]amino}pyrido[2,3-d]pyrimidin-7(8H)-one | US10233188, Example 10 | US10800783, Example 10 | US11396512, Example 10 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H27F2N5O4S |
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| Mol. Mass. | 471.521 |
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| SMILES | C[C@@]1(O)CCC[C@H]1n1c2nc(NC3CCN(CC3)S(C)(=O)=O)ncc2cc(C(F)F)c1=O |r| |
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| Structure | 
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