| Reaction Details |
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 | Report a problem with these data |
| Target | Serine/threonine-protein kinase 3 |
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| Ligand | BDBM461378 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Biochemical LanthaScreen Eu Kinase Binding Assay |
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| IC50 | <100±n/a nM |
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| Citation |  Petrassi, HM; Peram Surakattula, MM; Maedler, K; Ardestani, A; Roland, JT; Baguley, TD; Tremblay, MS; Shen, W; Schultz, PG; Chatterjee, AK Composition and methods for inhibiting mammalian sterile 20-like kinase 1 US Patent US11427560 Publication Date 8/30/2022 |
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| More Info.: | Get all data from this article, Assay Method |
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| Serine/threonine-protein kinase 3 |
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| Name: | Serine/threonine-protein kinase 3 |
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| Synonyms: | KRS1 | MST-2 | MST2 | Mammalian STE20-like protein kinase 2 | STE20-Like Kinase MST2 | STK3 | STK3_HUMAN | Serine/threonine-protein kinase 3 | Serine/threonine-protein kinase 3 (MST2) | Serine/threonine-protein kinase 3/4 | Serine/threonine-protein kinase Krs-1 | Serine/threonine-protein kinase MST2 |
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| Type: | Serine/threonine-protein kinase |
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| Mol. Mass.: | 56284.87 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 491 |
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| Sequence: | MEQPPAPKSKLKKLSEDSLTKQPEEVFDVLEKLGEGSYGSVFKAIHKESGQVVAIKQVPV
ESDLQEIIKEISIMQQCDSPYVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLIE
DEIATILKSTLKGLEYLHFMRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNT
VIGTPFWMAPEVIQEIGYNCVADIWSLGITSIEMAEGKPPYADIHPMRAIFMIPTNPPPT
FRKPELWSDDFTDFVKKCLVKNPEQRATATQLLQHPFIKNAKPVSILRDLITEAMEIKAK
RHEEQQRELEEEEENSDEDELDSHTMVKTSVESVGTMRATSTMSEGAQTMIEHNSTMLES
DLGTMVINSEDEEEEDGTMKRNATSPQVQRPSFMDYFDKQDFKNKSHENCNQNMHEPFPM
SKNVFPDNWKVPQDGDFDFLKNLSLEELQMRLKALDPMMEREIEELRQRYTAKRQPILDA
MDAKKRRQQNF
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| BDBM461378 |
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| n/a |
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| Name | BDBM461378 |
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| Synonyms: | US10774068, Example 84 | US11427560, Example 84 |
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| Type | Small organic molecule |
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| Emp. Form. | C27H24ClN5O3 |
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| Mol. Mass. | 501.964 |
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| SMILES | CCOc1cc2ncc(C#N)c(Nc3ccc(OCc4ncccc4C)c(Cl)c3)c2cc1NC(C)=O |
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| Structure | 
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