| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Induced myeloid leukemia cell differentiation protein Mcl-1 [173-321]/Noxa BH3 Peptide |
|---|
| Ligand | BDBM571478 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | Protein-Protein Interaction Assay: MCL-1/Noxa BH3 Peptide (MCL-1 Assay) |
|---|
| IC50 | 0.330±n/a nM |
|---|
| Citation |  Thede, K; Mengel, A; Christ, C; Kuhnke, J; Johannes, SA; Buchgraber, P; Klar, U; Rauh, U; Kaulfuss, S; Fernandez-Montalvan, AE; Werbeck, N; Mönning, U; Nowak-Reppel, K; Wittrock, S; McKinney, D; Serrano-Wu, MH; Lemke, C; Fitzgerald, M; Nasveschuk, C; Lazarski, K; Ferrara, SJ; Furst, L; Wei, G; McCarren, PR; Harvey, RA Substituted macrocyclic indole derivatives US Patent US11440923 Publication Date 9/13/2022 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Induced myeloid leukemia cell differentiation protein Mcl-1 [173-321]/Noxa BH3 Peptide |
|---|
| Name: | Induced myeloid leukemia cell differentiation protein Mcl-1 [173-321]/Noxa BH3 Peptide |
|---|
| Synonyms: | MCL-1/Noxa BH3 Peptide |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | n/a |
|---|
| Description: | n/a |
|---|
| Components: | This complex has 3 components. |
|---|
| Component 1 |
| Name: | Induced myeloid leukemia cell differentiation protein Mcl-1 [173-321] |
|---|
| Synonyms: | BCL2L3 | MCL1 | MCL1_HUMAN |
|---|
| Type: | n/a |
|---|
| Mol. Mass.: | 17056.39 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Q07820[173-321] |
|---|
| Residue: | 149 |
|---|
| Sequence: | ELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGML
RKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAE
SITDVLVRTKRDWLVKQRGWDGFVEFFHV
|
|
|
|---|
| Component 2 |
| Name: | Maltose/maltodextrin import ATP-binding protein MalK |
|---|
| Synonyms: | MALK_ECOLI | malK |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 40990.98 |
|---|
| Organism: | n/a |
|---|
| Description: | P68187 |
|---|
| Residue: | 371 |
|---|
| Sequence: | MASVQLQNVTKAWGEVVVSKDINLDIHEGEFVVFVGPSGCGKSTLLRMIAGLETITSGDL
FIGEKRMNDTPPAERGVGMVFQSYALYPHLSVAENMSFGLKLAGAKKEVINQRVNQVAEV
LQLAHLLDRKPKALSGGQRQRVAIGRTLVAEPSVFLLDEPLSNLDAALRVQMRIEISRLH
KRLGRTMIYVTHDQVEAMTLADKIVVLDAGRVAQVGKPLELYHYPADRFVAGFIGSPKMN
FLPVKVTATAIDQVQVELPMPNRQQVWLPVESRDVQVGANMSLGIRPEHLLPSDIADVIL
EGEVQVVEQLGNETQIHIQIPSIRQNLVYRQNDVVLVEEGATFAIGLPPERCHLFREDGT
ACRRLHKEPGV
|
|
|
|---|
| Component 3 |
| Name: | Phorbol-12-myristate-13-acetate-induced protein 1 [17-23,25-42,C24V] |
|---|
| Synonyms: | APR_HUMAN | Immediate-early-response protein APR | NOXA | PMA-induced protein 1 | PMAIP1 | Protein Noxa |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 3072.54 |
|---|
| Organism: | Human |
|---|
| Description: | Biotin-PEG2-PEG2-PAELEVE-Nva-ATQLRRFGDKLNFRQKLL-amide |
|---|
| Residue: | 26 |
|---|
| Sequence: | PAELEVEVATQLRRFGDKLNFRQKLL
|
|
|
|---|
| BDBM571478 |
|---|
| n/a |
|---|
| Name | BDBM571478 |
|---|
| Synonyms: | (+)-4-chloro-3-ethyl-7-{3-[(6-fluoronaphthalen-1-yl)oxy]propyl}-15-(2-methoxyethyl)-2-methyl-2,10,11,12,13,15-hexahydropyrazolo[4′,3′:9,10][1,6]oxazacycloundecino[8,7,6-hi]indole-8-carboxylic Acid—N-ethylethanamine Salt (Enantiomer 1) | US11440923, Example 42 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C36H39ClFN3O5 |
|---|
| Mol. Mass. | 648.163 |
|---|
| SMILES | CCc1c-2c(nn1C)C(CCOC)OCCCCn1c(C(O)=O)c(CCCOc3cccc4cc(F)ccc34)c3ccc(Cl)c-2c13 |
|---|
| Structure | 
|
|---|
Search and Browse
