| Reaction Details |
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 | Report a problem with these data |
| Target | Induced myeloid leukemia cell differentiation protein Mcl-1 [173-321]/Noxa BH3 Peptide |
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| Ligand | BDBM572155 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | MCL-1/Noxa BH3 Peptide (MCL-1 Assay) |
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| IC50 | 0.890±n/a nM |
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| Citation |  Thede, K; Mengel, A; Christ, C; Kuhnke, J; Johannes, SA; Buchgraber, P; Klar, U; Rauh, U; Kaulfuss, S; Fernandez-Montalvan, AE; Werbeck, N; Moenning, U; Nowak-Reppel, K; Mortier, JX; McCarren, PR; Serrano-Wu, MH; Lemke, C; McKinney, D; Fitzgerald, M; Nasveschuk, C; Lazarski, K; Ferrara, SJ; Furst, L; Wei, G; Harvey, RA; Payne, D; Pesnot, T; Wilson, C Macrocyclic chlorine substituted indole derivatives US Patent US11447504 Publication Date 9/20/2022 |
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| More Info.: | Get all data from this article, Assay Method |
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| |
| Induced myeloid leukemia cell differentiation protein Mcl-1 [173-321]/Noxa BH3 Peptide |
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| Name: | Induced myeloid leukemia cell differentiation protein Mcl-1 [173-321]/Noxa BH3 Peptide |
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| Synonyms: | MCL-1/Noxa BH3 Peptide |
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| Type: | Protein |
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| Mol. Mass.: | n/a |
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| Description: | n/a |
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| Components: | This complex has 3 components. |
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| Component 1 |
| Name: | Induced myeloid leukemia cell differentiation protein Mcl-1 [173-321] |
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| Synonyms: | BCL2L3 | MCL1 | MCL1_HUMAN |
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| Type: | n/a |
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| Mol. Mass.: | 17056.39 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q07820[173-321] |
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| Residue: | 149 |
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| Sequence: | ELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGML
RKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAE
SITDVLVRTKRDWLVKQRGWDGFVEFFHV
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| Component 2 |
| Name: | Maltose/maltodextrin import ATP-binding protein MalK |
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| Synonyms: | MALK_ECOLI | malK |
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| Type: | Protein |
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| Mol. Mass.: | 40990.98 |
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| Organism: | n/a |
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| Description: | P68187 |
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| Residue: | 371 |
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| Sequence: | MASVQLQNVTKAWGEVVVSKDINLDIHEGEFVVFVGPSGCGKSTLLRMIAGLETITSGDL
FIGEKRMNDTPPAERGVGMVFQSYALYPHLSVAENMSFGLKLAGAKKEVINQRVNQVAEV
LQLAHLLDRKPKALSGGQRQRVAIGRTLVAEPSVFLLDEPLSNLDAALRVQMRIEISRLH
KRLGRTMIYVTHDQVEAMTLADKIVVLDAGRVAQVGKPLELYHYPADRFVAGFIGSPKMN
FLPVKVTATAIDQVQVELPMPNRQQVWLPVESRDVQVGANMSLGIRPEHLLPSDIADVIL
EGEVQVVEQLGNETQIHIQIPSIRQNLVYRQNDVVLVEEGATFAIGLPPERCHLFREDGT
ACRRLHKEPGV
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| Component 3 |
| Name: | Phorbol-12-myristate-13-acetate-induced protein 1 [17-23,25-42,C24V] |
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| Synonyms: | APR_HUMAN | Immediate-early-response protein APR | NOXA | PMA-induced protein 1 | PMAIP1 | Protein Noxa |
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| Type: | Protein |
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| Mol. Mass.: | 3072.54 |
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| Organism: | Human |
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| Description: | Biotin-PEG2-PEG2-PAELEVE-Nva-ATQLRRFGDKLNFRQKLL-amide |
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| Residue: | 26 |
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| Sequence: | PAELEVEVATQLRRFGDKLNFRQKLL
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| BDBM572155 |
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| n/a |
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| Name | BDBM572155 |
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| Synonyms: | (rac)-4-chloro-3-ethyl-1-[2-(morpholin-4-yl)ethyl]-7-[3-(naphthalen-1-yloxy)propyl]-1,10,11,12,13,15-hexahydropyrazolo[4′,3′:9,10][1,6]oxazacycloundecino[8,7,6-hi]indole-8-carboxylic Acid | US11447504, Example 8 | US11447504, Example 9 |
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| Type | Small organic molecule |
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| Emp. Form. | C37H41ClN4O5 |
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| Mol. Mass. | 657.198 |
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| SMILES | Cc1nn(CCN2CCOCC2)c2COCCCCn3c(C(O)=O)c(CCCOc4cccc5ccccc45)c4ccc(Cl)c(-c12)c34 |
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| Structure | 
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