Reaction Details |
| Report a problem with these data |
Target | Proto-oncogene tyrosine-protein kinase receptor Ret [G810S] |
---|
Ligand | BDBM577045 |
---|
Substrate/Competitor | n/a |
---|
IC50 | 1.80±n/a nM |
---|
Citation | Walls, SM; Ren, L; Ramann, GA; Moreno, DA; Metcalf, AT; McFaddin, EA; Kolakowski, GR; Blake, JF; Dai, D; Haas, J; Jiang, Y; Kahn, D Substituted pyrazolyl[4,3-c]pyridine compounds as RET kinase inhibitors US Patent US11472802 Publication Date 10/18/2022 |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Proto-oncogene tyrosine-protein kinase receptor Ret [G810S] |
---|
Name: | Proto-oncogene tyrosine-protein kinase receptor Ret [G810S] |
Synonyms: | CDHF12 | CDHR16 | PTC | RET | RET51 | RET_HUMAN |
Type: | Protein |
Mol. Mass.: | 124348.32 |
Organism: | Homo sapiens (Human) |
Description: | P07949[G810S] |
Residue: | 1114 |
Sequence: | MAKATSGAAGLRLLLLLLLPLLGKVALGLYFSRDAYWEKLYVDQAAGTPLLYVHALRDAP
EEVPSFRLGQHLYGTYRTRLHENNWICIQEDTGLLYLNRSLDHSSWEKLSVRNRGFPLLT
VYLKVFLSPTSLREGECQWPGCARVYFSFFNTSFPACSSLKPRELCFPETRPSFRIRENR
PPGTFHQFRLLPVQFLCPNISVAYRLLEGEGLPFRCAPDSLEVSTRWALDREQREKYELV
AVCTVHAGAREEVVMVPFPVTVYDEDDSAPTFPAGVDTASAVVEFKRKEDTVVATLRVFD
ADVVPASGELVRRYTSTLLPGDTWAQQTFRVEHWPNETSVQANGSFVRATVHDYRLVLNR
NLSISENRTMQLAVLVNDSDFQGPGAGVLLLHFNVSVLPVSLHLPSTYSLSVSRRARRFA
QIGKVCVENCQAFSGINVQYKLHSSGANCSTLGVVTSAEDTSGILFVNDTKALRRPKCAE
LHYMVVATDQQTSRQAQAQLLVTVEGSYVAEEAGCPLSCAVSKRRLECEECGGLGSPTGR
CEWRQGDGKGITRNFSTCSPSTKTCPDGHCDVVETQDINICPQDCLRGSIVGGHEPGEPR
GIKAGYGTCNCFPEEEKCFCEPEDIQDPLCDELCRTVIAAAVLFSFIVSVLLSAFCIHCY
HKFAHKPPISSAEMTFRRPAQAFPVSYSSSGARRPSLDSMENQVSVDAFKILEDPKWEFP
RKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLK
QVNHPHVIKLYGACSQDGPLLLIVEYAKYSSLRGFLRESRKVGPGYLGSGGSRNSSSLDH
PDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVY
EEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERL
FNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVKRRDYLDLAA
STPSDSLIYDDGLSEEETPLVDCNNAPLPRALPSTWIENKLYGMSDPNWPGESPVPLTRA
DGTNTGFPRYPNDSVYANWMLSPSAAKLMDTFDS
|
|
|
BDBM577045 |
---|
n/a |
---|
Name | BDBM577045 |
Synonyms: | US11472802, Example 51 |
Type | Small organic molecule |
Emp. Form. | C19H20ClN7O |
Mol. Mass. | 397.861 |
SMILES | CC(C)n1nc(-c2noc(C3CC3)c2-c2cc(C)[nH]n2)c2c(N)ncc(Cl)c12 |
Structure |
|