| Reaction Details |
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 | Report a problem with these data |
| Target | Eukaryotic translation initiation factor 2-alpha kinase 3 [540-1115] |
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| Ligand | BDBM482164 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | PERK enzyme assays |
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| IC50 | <16±n/a nM |
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| Citation |  Bindi, S; Carenzi, D; Motto, I; Pulici, M N-(substituted-phenyl)-sulfonamide derivatives as kinase inhibitors US Patent US11491158 Publication Date 11/8/2022 |
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| More Info.: | Get all data from this article, Assay Method |
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| Eukaryotic translation initiation factor 2-alpha kinase 3 [540-1115] |
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| Name: | Eukaryotic translation initiation factor 2-alpha kinase 3 [540-1115] |
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| Synonyms: | E2AK3_HUMAN | EIF2AK3 | PEK | PERK |
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| Type: | Enzyme |
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| Mol. Mass.: | 65443.31 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q9NZJ5 [540-1115] |
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| Residue: | 576 |
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| Sequence: | VRRLFHPHPHRQRKESETQCQTENKYDSVSGEANDSSWNDIKNSGYISRYLTDFEPIQCL
GRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELAREKVMREVKALAKLEHPGIVRYFNAWL
EAPPEKWQEKMDEIWLKDESTDWPLSSPSPMDAPSVKIRRMDPFATKEHIEIIAPSPQRS
RSFSVGISCDQTSSSESQFSPLEFSGMDHEDISESVDAAYNLQDSCLTDCDVEDGTMDGN
DEGHSFELCPSEASPYVRSRERTSSSIVFEDSGCDNASSKEEPKTNRLHIGNHCANKLTA
FKPTSSKSSSEATLSISPPRPTTLSLDLTKNTTEKLQPSSPKVYLYIQMQLCRKENLKDW
MNGRCTIEERERSVCLHIFLQIAEAVEFLHSKGLMHRDLKPSNIFFTMDDVVKVGDFGLV
TAMDQDEEEQTVLTPMPAYARHTGQVGTKLYMSPEQIHGNSYSHKVDIFSLGLILFELLY
PFSTQMERVRTLTDVRNLKFPPLFTQKYPCEYVMVQDMLSPSPMERPEAINIIENAVFED
LDFPGKTVLRQRSRSLSSSGTKHSRQSNNSHSPLPS
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| BDBM482164 |
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| n/a |
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| Name | BDBM482164 |
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| Synonyms: | N-{3-[4-Amino-7-(1-methyl-piperidin-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl]-2-fluoro-phenyl}-3-chloro-4-methoxy-benzenesulfonamide | US10918642, Cmpd # 4 | US11491158, Cmpd 4 |
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| Type | Small organic molecule |
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| Emp. Form. | C25H26ClFN6O3S |
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| Mol. Mass. | 545.029 |
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| SMILES | COc1ccc(cc1Cl)S(=O)(=O)Nc1cccc(-c2cn(C3CCN(C)CC3)c3ncnc(N)c23)c1F |
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| Structure | 
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