Reaction Details | |||
---|---|---|---|
Report a problem with these data | |||
Target | G protein-activated inward rectifier potassium channel 1/4 | ||
Ligand | BDBM585711 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | IonWorks Quattro system | ||
IC50 | 33.0±n/a nM | ||
Citation | Barbe, G; Bebernitz, GR; Geng, S; Gulgeze Efthymiou, HB; Liao, L; Ma, F; Mo, R; Parker, DT; Peng, Y; Peukert, S; Smith, N; Yamada, K; Yasoshima, K Naphthyridinone derivatives and their use in the treatment of arrhythmia US Patent US11530213 Publication Date 12/20/2022 | ||
More Info.: | Get all data from this article, Assay Method | ||
G protein-activated inward rectifier potassium channel 1/4 | |||
Name: | G protein-activated inward rectifier potassium channel 1/4 | ||
Synonyms: | GIRK1/4 channels | Kir3.1/Kir3.4 | ||
Type: | PROTEIN | ||
Mol. Mass.: | n/a | ||
Description: | n/a | ||
Components: | This complex has 2 components. | ||
Component 1 | |||
Name: | G protein-activated inward rectifier potassium channel 1 | ||
Synonyms: | GIRK-1 | GIRK1 | Inward rectifier K(+) channel Kir3.1 | KCNJ3 | KCNJ3_HUMAN | Potassium channel, inwardly rectifying subfamily J member 3 | ||
Type: | PROTEIN | ||
Mol. Mass.: | 56610.74 | ||
Organism: | Homo sapiens (Human) | ||
Description: | ChEMBL_107915 | ||
Residue: | 501 | ||
Sequence: |
| ||
Component 2 | |||
Name: | G protein-activated inward rectifier potassium channel 4 | ||
Synonyms: | CIR | Cardiac inward rectifier | GIRK-4 | GIRK4 | Heart KATP channel | IRK-4 | Inward rectifier K(+) channel Kir3.4 | KATP-1 | KCNJ5 | KCNJ5_HUMAN | Potassium channel, inwardly rectifying subfamily J member 5 | ||
Type: | PROTEIN | ||
Mol. Mass.: | 47658.06 | ||
Organism: | Homo sapiens (Human) | ||
Description: | ChEMBL_107914 | ||
Residue: | 419 | ||
Sequence: |
| ||
BDBM585711 | |||
n/a | |||
Name | BDBM585711 | ||
Synonyms: | 8-chloro-1-(2,6-dichloro-4- fluorophenyl)-5-(2-(2-(2-(2- hydroxyethoxy)ethoxy)ethoxy)eth- oxy)-2-methyl-1,6-naphthyridin- 4(1H)-one | US11530213, Example 32 | ||
Type | Small organic molecule | ||
Emp. Form. | C23H24Cl3FN2O6 | ||
Mol. Mass. | 549.804 | ||
SMILES | Cc1cc(=O)c2c(OCCOCCOCCOCCO)ncc(Cl)c2n1-c1c(Cl)cc(F)cc1Cl |(11.85,-4.94,;10.52,-4.17,;9.18,-4.94,;7.85,-4.17,;6.51,-4.94,;7.85,-2.63,;6.51,-1.86,;5.18,-2.63,;3.85,-1.86,;2.51,-2.63,;1.18,-1.86,;-.15,-2.63,;-1.49,-1.86,;-2.82,-2.63,;-4.15,-1.86,;-5.49,-2.63,;-6.82,-1.86,;-8.16,-2.63,;-9.49,-1.86,;-10.82,-2.63,;6.51,-.32,;7.85,.45,;9.18,-.32,;10.52,.45,;9.18,-1.86,;10.52,-2.63,;11.85,-1.86,;13.18,-2.63,;13.18,-4.17,;14.52,-1.86,;14.52,-.32,;15.85,.45,;13.18,.45,;11.85,-.32,;11.22,1.09,)| | ||
Structure |