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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | G protein-activated inward rectifier potassium channel 1/4 | ||
| Ligand | BDBM585723 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | IonWorks Quattro system | ||
| IC50 | 56.0±n/a nM | ||
| Citation |  Barbe, G; Bebernitz, GR; Geng, S; Gulgeze Efthymiou, HB; Liao, L; Ma, F; Mo, R; Parker, DT; Peng, Y; Peukert, S; Smith, N; Yamada, K; Yasoshima, K Naphthyridinone derivatives and their use in the treatment of arrhythmia US Patent US11530213 Publication Date 12/20/2022 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| G protein-activated inward rectifier potassium channel 1/4 | |||
| Name: | G protein-activated inward rectifier potassium channel 1/4 | ||
| Synonyms: | GIRK1/4 channels | Kir3.1/Kir3.4 | ||
| Type: | PROTEIN | ||
| Mol. Mass.: | n/a | ||
| Description: | n/a | ||
| Components: | This complex has 2 components. | ||
| Component 1 | |||
| Name: | G protein-activated inward rectifier potassium channel 1 | ||
| Synonyms: | GIRK-1 | GIRK1 | Inward rectifier K(+) channel Kir3.1 | KCNJ3 | KCNJ3_HUMAN | Potassium channel, inwardly rectifying subfamily J member 3 | ||
| Type: | PROTEIN | ||
| Mol. Mass.: | 56610.74 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | ChEMBL_107915 | ||
| Residue: | 501 | ||
| Sequence: |
| ||
| Component 2 | |||
| Name: | G protein-activated inward rectifier potassium channel 4 | ||
| Synonyms: | CIR | Cardiac inward rectifier | GIRK-4 | GIRK4 | Heart KATP channel | IRK-4 | Inward rectifier K(+) channel Kir3.4 | KATP-1 | KCNJ5 | KCNJ5_HUMAN | Potassium channel, inwardly rectifying subfamily J member 5 | ||
| Type: | PROTEIN | ||
| Mol. Mass.: | 47658.06 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | ChEMBL_107914 | ||
| Residue: | 419 | ||
| Sequence: |
| ||
| BDBM585723 | |||
| n/a | |||
| Name | BDBM585723 | ||
| Synonyms: | 3,5-dichloro-4-(8-chloro-5-((2- hydroxyethoxy)amino)-2-methyl-4- oxo-1,6-naphthyridin-1(4H)- yl)benzonitrile | US11530213, Example 44 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C18H13Cl3N4O3 | ||
| Mol. Mass. | 439.68 | ||
| SMILES | Cc1cc(=O)c2c(NOCCO)ncc(Cl)c2n1-c1c(Cl)cc(cc1Cl)C#N |(4,.3,;2.67,-.47,;2.67,-2.01,;1.33,-2.78,;1.33,-4.32,;,-2.01,;-1.33,-2.78,;-1.33,-4.32,;-2.67,-5.09,;-2.67,-6.63,;-4,-7.4,;-4,-8.94,;-2.67,-2.01,;-2.67,-.47,;-1.33,.3,;-1.33,1.84,;,-.47,;1.33,.3,;1.33,2.78,;2.67,3.55,;4,2.78,;2.67,5.09,;1.33,5.91,;,5.09,;,3.55,;-1.33,2.78,;1.33,7.45,;1.33,8.99,)| | ||
| Structure | 
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