Reaction Details |
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Target | Dipeptidyl peptidase 2 |
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Ligand | BDBM514538 |
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Substrate/Competitor | n/a |
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Meas. Tech. | EnPlex (purified enzyme activity assay) |
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IC50 | 92160±n/a nM |
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Citation | Bachovchin, WW; Lai, H; Wu, W Combination therapies using caspase-1 dependent anticancer agents and PGE2 antagonists US Patent US11559537 Publication Date 1/24/2023 |
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More Info.: | Get all data from this article, Assay Method |
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Dipeptidyl peptidase 2 |
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Name: | Dipeptidyl peptidase 2 |
Synonyms: | DAP II | DPP2 | DPP2_HUMAN | DPP7 | Dipeptidyl aminopeptidase II | Dipeptidyl peptidase 2 (DPP II) | Dipeptidyl peptidase 2 (DPP2) | Dipeptidyl peptidase II (DDP-II) | Dipeptidyl peptidase II (DPP II) | Dipeptidyl peptidase II (DPP2) | Dipeptidyl peptidase II and dipeptidyl peptidase IV (DPP2 and DPP4) | QPP | carboxytripeptidase | dipeptidyl arylamidase II | dipeptidyl(amino)peptidase II | dipeptidylarylamidase |
Type: | Protein |
Mol. Mass.: | 54339.29 |
Organism: | Homo sapiens (Human) |
Description: | Q9UHL4 |
Residue: | 492 |
Sequence: | MGSAPWAPVLLLALGLRGLQAGARRAPDPGFQERFFQQRLDHFNFERFGNKTFPQRFLVS
DRFWVRGEGPIFFYTGNEGDVWAFANNSAFVAELAAERGALLVFAEHRYYGKSLPFGAQS
TQRGHTELLTVEQALADFAELLRALRRDLGAQDAPAIAFGGSYGGMLSAYLRMKYPHLVA
GALAASAPVLAVAGLGDSNQFFRDVTADFEGQSPKCTQGVREAFRQIKDLFLQGAYDTVR
WEFGTCQPLSDEKDLTQLFMFARNAFTVLAMMDYPYPTDFLGPLPANPVKVGCDRLLSEA
QRITGLRALAGLVYNASGSEHCYDIYRLYHSCADPTGCGTGPDARAWDYQACTEINLTFA
SNNVTDMFPDLPFTDELRQRYCLDTWGVWPRPDWLLTSFWGGDLRAASNIIFSNGNLDPW
AGGGIRRNLSASVIAVTIQGGAHHLDLRASHPEDPASVVEARKLEATIIGEWVKAARREQ
QPALRGGPRLSL
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BDBM514538 |
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n/a |
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Name | BDBM514538 |
Synonyms: | US11096924, DASH-inhibitors 5316 | US11559537, Compound 5316 |
Type | Small organic molecule |
Emp. Form. | C12H14FN3O2 |
Mol. Mass. | 251.2569 |
SMILES | N[C@@H](CC(N)=O)C(=O)N1Cc2ccc(F)cc2C1 |r| |
Structure |
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