| Reaction Details |
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 | Report a problem with these data |
| Target | Isoform PDE4B2 of cAMP-specific 3',5'-cyclic phosphodiesterase 4B |
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| Ligand | BDBM589897 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Cytokine Assays |
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| IC50 | 0.490±n/a nM |
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| Citation |  Strohbach, JW; Akama, T; Blakemore, DC; Jacobs, RT; Jones, P; Limburg, DC; Oderinde, MS; Perry, MA; Plattner, JJ; Torella, RF; Zhou, Y; Yeoh, TY Substituted 1,2-oxaborolan-2-ols as PDE4 inhibitors US Patent US11559538 Publication Date 1/24/2023 |
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| More Info.: | Get all data from this article, Assay Method |
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| Isoform PDE4B2 of cAMP-specific 3',5'-cyclic phosphodiesterase 4B |
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| Name: | Isoform PDE4B2 of cAMP-specific 3',5'-cyclic phosphodiesterase 4B (PDE4B2) |
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| Synonyms: | DPDE4 | PDE4B | PDE4B2 | PDE4B_HUMAN | cAMP-specific 3',5'-cyclic phosphodiesterase 4B (PDE4B2) | phosphodiesterase 4B2 |
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| Type: | Enzyme |
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| Mol. Mass.: | 64320.36 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q07343-2 |
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| Residue: | 564 |
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| Sequence: | MKEHGGTFSSTGISGGSGDSAMDSLQPLQPNYMPVCLFAEESYQKLAMETLEELDWCLDQ
LETIQTYRSVSEMASNKFKRMLNRELTHLSEMSRSGNQVSEYISNTFLDKQNDVEIPSPT
QKDREKKKKQQLMTQISGVKKLMHSSSLNNTSISRFGVNTENEDHLAKELEDLNKWGLNI
FNVAGYSHNRPLTCIMYAIFQERDLLKTFRISSDTFITYMMTLEDHYHSDVAYHNSLHAA
DVAQSTHVLLSTPALDAVFTDLEILAAIFAAAIHDVDHPGVSNQFLINTNSELALMYNDE
SVLENHHLAVGFKLLQEEHCDIFMNLTKKQRQTLRKMVIDMVLATDMSKHMSLLADLKTM
VETKKVTSSGVLLLDNYTDRIQVLRNMVHCADLSNPTKSLELYRQWTDRIMEEFFQQGDK
ERERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETWADLVQPDAQDILDTLEDNRNWY
QSMIPQSPSPPLDEQNRDCQGLMEKFQFELTLDEEDSEGPEKEGEGHSYFSSTKTLCVID
PENRDSLGETDIDIATEDKSPVDT
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| BDBM589897 |
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| n/a |
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| Name | BDBM589897 |
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| Synonyms: | US11559538, Example 149 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H24BNO4 |
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| Mol. Mass. | 353.22 |
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| SMILES | COc1ccc(cc1OC1CCCC1)-c1cncc(c1)C1COB(O)C1 |
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| Structure | 
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