Ki Summary

Reaction Details

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Target

GTPase NRas [G12C]

Ligand

BDBM591612

Substrate/Competitor

n/a

Meas. Tech.

Biochemical Assay

IC50

<10.00±n/a nM

Citation

Koltun, ES; Cregg, J; Gill, AL; Buckl, A; Liu, Y Ras inhibitors US Patent US11566007 Publication Date 1/31/2023

More Info.:

Get all data from this article, Assay Method

GTPase NRas [G12C]

Name:

GTPase NRas [G12C]

Synonyms:

HRAS1 | NRAS | RASN_HUMAN

Type:

PROTEIN

Mol. Mass.:

21270.00

Organism:

Homo sapiens (Human)

Description:

n/a

Residue:

189

Sequence:

MTEYKLVVVGACGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAG
QEEYSAMRDQYMRTGEGFLCVFAINNSKSFADINLYREQIKRVKDSDDVPMVLVGNKCDL
PTRTVDTKQAHELAKSYGIPFIETSAKTRQGVEDAFYTLVREIRQYRMKKLNSSDDGTQG
CMGLPCVVM

BDBM591612

n/a

Name

BDBM591612

Synonyms:

US11566007, Example A290

Type

Small organic molecule

Emp. Form.

C56H74N8O7

Mol. Mass.

971.2362

SMILES

CCn1c(c2CC(C)(C)COC(=O)[C@@H]3CCCN(N3)C(=O)[C@H](Cc3cccc(c3)-c3ccc1c2c3)NC(=O)[C@H](C(C)C)N(C)C(=O)[C@H]1CCN(C1)C(=O)C#CC(C)(C)N(C)C)-c1cccnc1[C@H](C)OC |r,wU:21.39,38.46,67.74,wD:13.18,46.50,(-9.42,-8.67,;-10.19,-7.34,;-9.42,-6,;-10.32,-4.76,;-9.42,-3.51,;-9.42,-1.97,;-8.08,-1.2,;-6.6,-.8,;-6.99,-2.29,;-7.94,.63,;-6.61,1.4,;-6.61,2.94,;-7.94,3.71,;-5.27,3.71,;-5.27,5.25,;-3.94,6.02,;-2.6,5.25,;-2.6,3.71,;-3.94,2.94,;-1.27,2.94,;.06,3.71,;-1.27,1.4,;-2.6,.63,;-2.6,-.91,;-1.27,-1.68,;-1.27,-3.22,;-2.6,-3.99,;-3.94,-3.26,;-3.94,-1.68,;-5.29,-3.99,;-5.29,-5.53,;-6.62,-6.3,;-7.95,-5.53,;-7.95,-3.99,;-6.62,-3.22,;.06,.63,;1.4,1.4,;1.4,2.94,;2.73,.63,;2.73,-.91,;4.06,-1.68,;1.4,-1.68,;4.06,1.4,;4.06,2.94,;5.4,.63,;5.4,-.91,;6.73,1.4,;8.2,.92,;9.1,2.17,;8.2,3.41,;6.73,2.94,;8.59,4.9,;7.51,5.99,;10.08,5.3,;11.57,5.7,;13.06,6.1,;14.15,5.01,;13.46,4.61,;13.46,7.58,;12.37,8.67,;14.94,7.98,;-11.86,-4.76,;-12.63,-6.09,;-14.17,-6.09,;-14.94,-4.76,;-14.17,-3.42,;-12.63,-3.42,;-11.86,-2.09,;-10.32,-2.09,;-12.63,-.76,;-11.86,.58,)|

Structure