| Reaction Details |
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 | Report a problem with these data |
| Target | Ubiquitin carboxyl-terminal hydrolase 30 [57-517] |
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| Ligand | BDBM592755 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | USP30 Enzymatic Assay (Rhodamine Assay) |
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| IC50 | 37.0±n/a nM |
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| Citation |  Butler, JR; Erlanson, D; Graceffa, R; Iwig, J; Jeong, JW; White, RD; Wu, Y; Yi, S; Zheng, XM; McFarland, JM; Banerjee, A N-cyano-7-azanorbornane derivatives and uses thereof US Patent US11572374 Publication Date 2/7/2023 |
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| More Info.: | Get all data from this article, Assay Method |
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| Ubiquitin carboxyl-terminal hydrolase 30 [57-517] |
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| Name: | Ubiquitin carboxyl-terminal hydrolase 30 [57-517] |
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| Synonyms: | UBP30_HUMAN | USP30 | Ubiquitin carboxyl-terminal hydrolase 30 (USP30)(57-517) |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 52599.88 |
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| Organism: | Homo sapiens (Human) |
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| Description: | aa 57-517 |
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| Residue: | 461 |
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| Sequence: | TERKKRRKGLVPGLVNLGNTCFMNSLLQGLSACPAFIRWLEEFTSQYSRDQKEPPSHQYL
SLTLLHLLKALSCQEVTDDEVLDASCLLDVLRMYRWQISSFEEQDAHELFHVITSSLEDE
RDRQPRVTHLFDVHSLEQQSEITPKQITCRTRGSPHPTSNHWKSQHPFHGRLTSNMVCKH
CEHQSPVRFDTFDSLSLSIPAATWGHPLTLDHCLHHFISSESVRDVVCDNCTKIEAKGTL
NGEKVEHQRTTFVKQLKLGKLPQCLCIHLQRLSWSSHGTPLKRHEHVQFNEFLMMDIYKY
HLLGHKPSQHNPKLNKNPGPTLELQDGPGAPTPVLNQPGAPKTQIFMNGACSPSLLPTLS
APMPFPLPVVPDYSSSTYLFRLMAVVVHHGDMHSGHFVTYRRSPPSARNPLSTSNQWLWV
SDDTVRKASLQEVLSSSAYLLFYERVLSRMQHQSQECKSEE
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| BDBM592755 |
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| n/a |
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| Name | BDBM592755 |
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| Synonyms: | 2-chloro-N-((1R,2R,4S)-7-cyano-7- azabicyclo[2.2.1]heptan-2-yl)-4-(6-(1- cyanocyclopropyl)-2-pyridinyl)-N- methylbenzamide | US11572374, Example 7-17 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H22ClN5O |
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| Mol. Mass. | 431.917 |
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| SMILES | CN([C@@H]1C[C@@H]2CC[C@H]1N2C#N)C(=O)c1ccc(cc1Cl)-c1cccc(n1)C1(CC1)C#N |r,THB:9:8:6.5:2.3| |
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| Structure | 
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